BIOMAT Database Logo BIOMAT Database Logo

Cervicovaginal colposcopic lesions associated with 5 nonoxynol-9 vaginal spermicide formulations. 2008

Bryna Harwood, and Leslie A Meyn, and Susan A Ballagh, and Elizabeth G Raymond, and David F Archer, and Mitchell D Creinin
Department of Obstetrics and Gynecology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.

OBJECTIVE This study was undertaken to compare the colposcopic appearance of the cervicovaginal epithelium with spermicide use vs condom use in a low-risk population. METHODS This was an ancillary study of a trial comparing the efficacy of 5 nonoxynol-9 spermicides. A cohort of women who used condoms without spermicide served as a control group. Colposcopic examinations were performed during product use to identify genital lesions. RESULTS One hundred fifty-one participants had 1 or more follow-up examinations. At baseline, study groups differed only by the prevalence of baseline lesions. New lesions were identified at 49% of follow-up visits. Controlling for the presence of a baseline lesion, compared with condom use none of the spermicides were associated with an increase in new lesions (overall odds ratio, 0.8; 95% CI, 0.4-1.6; P = .5); and lesions characterized by epithelial disruption were less frequent with spermicide use (overall odds ratio, 0.3; 95% CI, 0.1-0.6; P < .001). CONCLUSIONS In a low-risk population, women who used nonoxynol-9 spermicides were less likely to have lesions with epithelial disruption, and equally likely to have any new lesion compared with condom use.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D011336 Probability The study of chance processes or the relative frequency characterizing a chance process. Probabilities
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D002584 Cervix Uteri The neck portion of the UTERUS between the lower isthmus and the VAGINA forming the cervical canal. Cervical Canal of the Uterus,Cervical Canal, Uterine,Ectocervix,Endocervical Canal,Endocervix,External Os Cervix,External Os of the Cervix,Uterine Cervical Canal,Cervix,Cervixes,Uterine Cervix,Canal, Endocervical,Canal, Uterine Cervical,Cervix, External Os,Cervix, Uterine,Endocervical Canals,Uterine Cervical Canals
D003127 Colposcopy The examination, therapy or surgery of the cervix and vagina by means of a specially designed endoscope introduced vaginally. Colposcopic Surgical Procedures,Surgical Procedures, Colposcopic,Colposcopic Surgery,Surgery, Colposcopic,Colposcopic Surgeries,Colposcopic Surgical Procedure,Colposcopies,Procedure, Colposcopic Surgical,Procedures, Colposcopic Surgical,Surgeries, Colposcopic,Surgical Procedure, Colposcopic
D003267 Contraception Prevention of CONCEPTION by blocking fertility temporarily, or permanently (STERILIZATION, REPRODUCTIVE). Common means of reversible contraception include NATURAL FAMILY PLANNING METHODS; CONTRACEPTIVE AGENTS; or CONTRACEPTIVE DEVICES. Birth Control,Contraceptive Methods,Female Contraception,Fertility Control,Inhibition of Fertilization,Male Contraception,Contraception, Female,Contraception, Male,Contraceptions, Female,Contraceptions, Male,Contraceptive Method,Female Contraceptions,Fertilization Inhibition,Male Contraceptions
D003274 Contraceptive Devices, Female Contraceptive devices used by females. Cervical Cap,Coiled Spring,Vaginal Diaphragm,Vaginal Rings,Vaginal Shield,Vaginal Sponge,Cap, Cervical,Caps, Cervical,Cervical Caps,Coiled Springs,Contraceptive Device, Female,Device, Female Contraceptive,Devices, Female Contraceptive,Diaphragm, Vaginal,Diaphragms, Vaginal,Female Contraceptive Device,Female Contraceptive Devices,Ring, Vaginal,Rings, Vaginal,Shield, Vaginal,Shields, Vaginal,Sponge, Vaginal,Sponges, Vaginal,Spring, Coiled,Springs, Coiled,Vaginal Diaphragms,Vaginal Ring,Vaginal Shields,Vaginal Sponges
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000282 Administration, Intravaginal The insertion of drugs into the vagina to treat local infections, neoplasms, or to induce labor. The dosage forms may include medicated pessaries, irrigation fluids, and suppositories. Administration, Vaginal,Drug Administration, Vaginal,Instillation, Vaginal,Intravaginal Administration,Vaginal Drug Administration,Vaginal Administration,Administration, Vaginal Drug,Administrations, Intravaginal,Administrations, Vaginal,Administrations, Vaginal Drug,Drug Administrations, Vaginal,Instillations, Vaginal,Intravaginal Administrations,Vaginal Administrations,Vaginal Drug Administrations,Vaginal Instillation,Vaginal Instillations

Related Publications

Bryna Harwood, and Leslie A Meyn, and Susan A Ballagh, and Elizabeth G Raymond, and David F Archer, and Mitchell D Creinin
Update on nonoxynol-9 as vaginal spermicide.
December 2008, The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception,
Bryna Harwood, and Leslie A Meyn, and Susan A Ballagh, and Elizabeth G Raymond, and David F Archer, and Mitchell D Creinin
Nonoxynol-9 spermicide contraception use--United States, 1999.
May 2002, MMWR. Morbidity and mortality weekly report,
Bryna Harwood, and Leslie A Meyn, and Susan A Ballagh, and Elizabeth G Raymond, and David F Archer, and Mitchell D Creinin
The spermicide nonoxynol-9 does not inactivate papillomavirus.
January 1992, Sexually transmitted diseases,
Bryna Harwood, and Leslie A Meyn, and Susan A Ballagh, and Elizabeth G Raymond, and David F Archer, and Mitchell D Creinin
Effect of the spermicide, nonoxynol 9, on vaginal permeability in normal and ovariectomized rabbits.
June 1996, Pharmaceutical research,
Bryna Harwood, and Leslie A Meyn, and Susan A Ballagh, and Elizabeth G Raymond, and David F Archer, and Mitchell D Creinin
Determination of the spermicide nonoxynol-9 in vaginal lavage by high-performance liquid chromatography.
February 1996, Journal of chromatography. B, Biomedical applications,
Bryna Harwood, and Leslie A Meyn, and Susan A Ballagh, and Elizabeth G Raymond, and David F Archer, and Mitchell D Creinin
Detection of the spermicide nonoxynol-9 via GC-MS.
May 2012, Journal of the American Society for Mass Spectrometry,
Bryna Harwood, and Leslie A Meyn, and Susan A Ballagh, and Elizabeth G Raymond, and David F Archer, and Mitchell D Creinin
Over-the-counter vaginal contraceptive and spermicide drug products containing nonoxynol 9; required labeling. Final rule.
December 2007, Federal register,
Bryna Harwood, and Leslie A Meyn, and Susan A Ballagh, and Elizabeth G Raymond, and David F Archer, and Mitchell D Creinin
Liver function tests in women using intravaginal spermicide nonoxynol-9.
February 1982, Fertility and sterility,
Bryna Harwood, and Leslie A Meyn, and Susan A Ballagh, and Elizabeth G Raymond, and David F Archer, and Mitchell D Creinin
The toxicity and local effects of the spermicide nonoxynol 9.
January 1992, Journal of acquired immune deficiency syndromes,
Bryna Harwood, and Leslie A Meyn, and Susan A Ballagh, and Elizabeth G Raymond, and David F Archer, and Mitchell D Creinin
Distribution of a spermicide containing Nonoxynol-9 in the vaginal canal and the upper female reproductive tract.
June 2001, Human reproduction (Oxford, England),
Copied contents to your clipboard!