BIOMAT Database Logo BIOMAT Database Logo

Chromosomal translocations involving BCL6 in MALT lymphoma. 2008

Hongtao Ye, and Ellen D Remstein, and Chris M Bacon, and Andrew G Nicholson, and Ahmet Dogan, and Ming-Qing Du

Chromosomal translocations involving BCL6 were detected in 7 out of 392 cases of MALT lymphoma by interphase fluorescence in situ hybridisation with a BCL6 break-apart probe. With the exception of BCL6 protein expression in 2 of the 7 cases, these BCL6 translocation-positive MALT lymphomas were histologically and immunophenotypically identical to classic cases.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D004268 DNA-Binding Proteins Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. DNA Helix Destabilizing Proteins,DNA-Binding Protein,Single-Stranded DNA Binding Proteins,DNA Binding Protein,DNA Single-Stranded Binding Protein,SS DNA BP,Single-Stranded DNA-Binding Protein,Binding Protein, DNA,DNA Binding Proteins,DNA Single Stranded Binding Protein,DNA-Binding Protein, Single-Stranded,Protein, DNA-Binding,Single Stranded DNA Binding Protein,Single Stranded DNA Binding Proteins
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012333 RNA, Messenger RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm. Messenger RNA,Messenger RNA, Polyadenylated,Poly(A) Tail,Poly(A)+ RNA,Poly(A)+ mRNA,RNA, Messenger, Polyadenylated,RNA, Polyadenylated,mRNA,mRNA, Non-Polyadenylated,mRNA, Polyadenylated,Non-Polyadenylated mRNA,Poly(A) RNA,Polyadenylated mRNA,Non Polyadenylated mRNA,Polyadenylated Messenger RNA,Polyadenylated RNA,RNA, Polyadenylated Messenger,mRNA, Non Polyadenylated
D014178 Translocation, Genetic A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome. Chromosomal Translocation,Translocation, Chromosomal,Chromosomal Translocations,Genetic Translocation,Genetic Translocations,Translocations, Chromosomal,Translocations, Genetic
D015972 Gene Expression Regulation, Neoplastic Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue. Neoplastic Gene Expression Regulation,Regulation of Gene Expression, Neoplastic,Regulation, Gene Expression, Neoplastic
D016130 Immunophenotyping Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry. Lymphocyte Immunophenotyping,Lymphocyte Subtyping,Immunologic Subtyping,Immunologic Subtypings,Lymphocyte Phenotyping,Subtyping, Immunologic,Subtypings, Immunologic,Immunophenotyping, Lymphocyte,Immunophenotypings,Immunophenotypings, Lymphocyte,Lymphocyte Immunophenotypings,Lymphocyte Phenotypings,Lymphocyte Subtypings,Phenotyping, Lymphocyte,Phenotypings, Lymphocyte,Subtyping, Lymphocyte,Subtypings, Lymphocyte
D017404 In Situ Hybridization, Fluorescence A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei. FISH Technique,Fluorescent in Situ Hybridization,Hybridization in Situ, Fluorescence,FISH Technic,Hybridization in Situ, Fluorescent,In Situ Hybridization, Fluorescent,FISH Technics,FISH Techniques,Technic, FISH,Technics, FISH,Technique, FISH,Techniques, FISH
D051560 Proto-Oncogene Proteins c-bcl-6 A DNA-binding protein that contains an N-terminal BTB (POZ) DOMAIN and C-terminal CYS2-HIS2 ZINC FINGERS. It represses GENETIC TRANSCRIPTION of target genes by recruiting HISTONE DEACETYLASES. Aberrant Blc-6 expression is associated with certain types of human B-CELL LYMPHOMA. bcl-6 Proto-Oncogene Proteins,c-bcl-6 Protein,c-bcl-6 Proto-Oncogene Proteins,B-Cell Lymphoma 6 Protein,Proto-Oncogene Protein bcl-6,Proto-Oncogene Protein c-bcl-6,Zinc Finger Protein 51,B Cell Lymphoma 6 Protein,Proto Oncogene Protein bcl 6,Proto Oncogene Protein c bcl 6,Proto Oncogene Proteins c bcl 6,Proto-Oncogene Proteins, bcl-6,Proto-Oncogene Proteins, c-bcl-6,bcl 6 Proto Oncogene Proteins,bcl-6, Proto-Oncogene Protein,c bcl 6 Protein,c bcl 6 Proto Oncogene Proteins,c-bcl-6, Proto-Oncogene Proteins
D018442 Lymphoma, B-Cell, Marginal Zone Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder. Lymphoma, Mucosa-Associated Lymphoid Tissue,MALT Lymphoma,Marginal Zone B-Cell Lymphoma,Lymphoma of Mucosa-Associated Lymphoid Tissue,Mucosa-Associated Lymphoid Tissue Lymphoma,Lymphoma of Mucosa Associated Lymphoid Tissue,Lymphoma, MALT,Lymphoma, Mucosa Associated Lymphoid Tissue,Lymphomas, MALT,MALT Lymphomas,Marginal Zone B Cell Lymphoma,Mucosa Associated Lymphoid Tissue Lymphoma

Related Publications

Hongtao Ye, and Ellen D Remstein, and Chris M Bacon, and Andrew G Nicholson, and Ahmet Dogan, and Ming-Qing Du
Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.
December 1995, The EMBO journal,
Hongtao Ye, and Ellen D Remstein, and Chris M Bacon, and Andrew G Nicholson, and Ahmet Dogan, and Ming-Qing Du
Primary Mediastinal Large B-Cell Lymphoma With Translocations Involving BCL6 and MYC (Double-Hit Lymphoma).
May 2016, American journal of clinical pathology,
Hongtao Ye, and Ellen D Remstein, and Chris M Bacon, and Andrew G Nicholson, and Ahmet Dogan, and Ming-Qing Du
Chromosomal translocations in Algerian Burkitt's lymphoma.
October 1983, Lancet (London, England),
Hongtao Ye, and Ellen D Remstein, and Chris M Bacon, and Andrew G Nicholson, and Ahmet Dogan, and Ming-Qing Du
Deregulation of BCL6 in non-Hodgkin lymphoma by insertion of IGH sequences in complex translocations involving band 3q27.
December 1998, Genes, chromosomes & cancer,
Hongtao Ye, and Ellen D Remstein, and Chris M Bacon, and Andrew G Nicholson, and Ahmet Dogan, and Ming-Qing Du
Translocations involving anaplastic lymphoma kinase (ALK).
September 2001, Oncogene,
Hongtao Ye, and Ellen D Remstein, and Chris M Bacon, and Andrew G Nicholson, and Ahmet Dogan, and Ming-Qing Du
Chromosomal translocations involving the MLL gene: molecular mechanisms.
September 2006, DNA repair,
Hongtao Ye, and Ellen D Remstein, and Chris M Bacon, and Andrew G Nicholson, and Ahmet Dogan, and Ming-Qing Du
Characterization of chromosomal aberrations in thymic MALT lymphoma.
February 2012, Pathology international,
Hongtao Ye, and Ellen D Remstein, and Chris M Bacon, and Andrew G Nicholson, and Ahmet Dogan, and Ming-Qing Du
T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma.
March 2003, Blood,
Hongtao Ye, and Ellen D Remstein, and Chris M Bacon, and Andrew G Nicholson, and Ahmet Dogan, and Ming-Qing Du
False CD10 positivity in MALT lymphoma involving kidney.
December 2022, Blood,
Hongtao Ye, and Ellen D Remstein, and Chris M Bacon, and Andrew G Nicholson, and Ahmet Dogan, and Ming-Qing Du
Translocations t(11;18)(q21;q21) and t(14;18)(q32;q21) are the main chromosomal abnormalities involving MLT/MALT1 in MALT lymphomas.
November 2003, Leukemia,
Copied contents to your clipboard!