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In the anaesthetized rabbit, L-NG-monomethyl-arginine (L-NMMA), a specific inhibitor of nitric oxide (NO) formation, was used to assess the role of endothelium-derived NO in the regulation of haemodynamics and noradrenaline release (RNA). L-NMMA dose-dependently increased mean arterial pressure and total peripheral resistance (TPR), but decreased heart rate, cardiac output and RNA. The curvilinear relationship between RNA and TPR obtained for L-NMMA was virtually identical with that produced by phenylephrine, indicating that L-NMMA-induced decreases in RNA are mediated by the baroreflex. Since the maximum RNA inhibition by L-NMMA was 69%, the counterregulation against peripheral vasodilatation by endothelium-derived NO accounts for 69% of basal RNA.
T Halbrügge, and
K Lütsch, and
A Thyen, and
K H Graefe
January 1993,
Journal of vascular research,
T Halbrügge, and
K Lütsch, and
A Thyen, and
K H Graefe
August 1996,
Circulation research,
T Halbrügge, and
K Lütsch, and
A Thyen, and
K H Graefe
February 1997,
The British journal of radiology,
T Halbrügge, and
K Lütsch, and
A Thyen, and
K H Graefe
December 1996,
Circulation,
T Halbrügge, and
K Lütsch, and
A Thyen, and
K H Graefe
December 2017,
Biological & pharmaceutical bulletin,
T Halbrügge, and
K Lütsch, and
A Thyen, and
K H Graefe
June 2002,
Circulation journal : official journal of the Japanese Circulation Society,
T Halbrügge, and
K Lütsch, and
A Thyen, and
K H Graefe
September 2004,
Nihon rinsho. Japanese journal of clinical medicine,
T Halbrügge, and
K Lütsch, and
A Thyen, and
K H Graefe
August 1993,
Experimental eye research,
T Halbrügge, and
K Lütsch, and
A Thyen, and
K H Graefe
June 1996,
Immunopharmacology,
T Halbrügge, and
K Lütsch, and
A Thyen, and
K H Graefe
August 1993,
Naunyn-Schmiedeberg's archives of pharmacology,
