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[Variability of the response to recombinant human erythropoietin in patients undergoing hemodialysis treatment]. 1991
A Baroni, and
G Airoldi, and
S Agliata, and
F Fortina, and
E Ragazzoni, and
A Cavagnino, and
A De Nigris, and
G Cametti, and
D Ferrero, and
A Fortina
Divisione Nefrologia, Ospedale SS. Trinità , Borgomanero, Novara.
The paper assesses the existence of possible interference between dialysis and the response to human recombinant erythropoietin administered i.v. in a group of patients undergoing regular dialysis. The results obtained show that the time taken to reach the set hemoglobin target (Hb 10 g%) was shorter in hemodiafiltered (HDF) patients compared to those receiving bicarbonate dialysis (BD). A plausible explantation may be the different depurative characteristics and the greater degree of biocompatibility of alternative dialysis which is able to achieve a more rapid cellular response to pharmacological stimulation.
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