Special attention has been paid to the new class of therapeutic agents namely calcimimetics for hemodialysis patients with secondary hyperparathyroidism (SHPT) . Several studies have demonstrated that calcimimetics not only reduce the concentrations of PTH, Ca, P and Ca x P but also improve bone metabolic marker and quality of life in hemodialysis patients. Recently, calcimimetics has been expected as a new strategy for SHPT in Japan. In this article, we reviewed the usefulness of calcimimetics for SHPT of dialysis patients.