Tryptophan hydroxylase gene (TPH1) and peripheral tryptophan levels in depression. 2008

Richard J Porter, and Roger T Mulder, and Peter R Joyce, and Allison L Miller, and Martin Kennedy
Department of Psychological Medicine, University of Otago, Christchurch, Christchurch, New Zealand. richard.porter@otago.ac.nz

BACKGROUND Genetic variants have been discovered in two genes encoding for tryptophan hydroxylase (TPH)-TPH1 and TPH2. Low tryptophan (TRP) levels are associated with depression and may arise because of stress. Evidence suggests that hypothalamic and peripheral 5HT systems have a significant role in appetite regulation, possibly a homeostatic mechanism in regulating peripheral TRP levels. METHODS We examined the association between a polymorphism in intron 7 of TPH1, 218A>C and plasma total TRP levels in 118 patients with major depression. RESULTS There was an interaction between 218A>C and gender in determining plasma TRP whereby presence of the 218C allele, in women, was associated with markedly reduced plasma TRP. CONCLUSIONS The study investigated only the TRP1 gene and did not use a haplotype analysis. The results only apply to a population of subjects suffering from major depression. CONCLUSIONS TPH1 may be associated with the regulation of peripheral tryptophan levels and therefore availability of tryptophan to the brain. This may have relevance to a range of neuropsychiatric conditions.

UI MeSH Term Description Entries
D007438 Introns Sequences of DNA in the genes that are located between the EXONS. They are transcribed along with the exons but are removed from the primary gene transcript by RNA SPLICING to leave mature RNA. Some introns code for separate genes. Intervening Sequences,Sequences, Intervening,Intervening Sequence,Intron,Sequence, Intervening
D008297 Male Males
D011110 Polymorphism, Genetic The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. Gene Polymorphism,Genetic Polymorphism,Polymorphism (Genetics),Genetic Polymorphisms,Gene Polymorphisms,Polymorphism, Gene,Polymorphisms (Genetics),Polymorphisms, Gene,Polymorphisms, Genetic
D011795 Surveys and Questionnaires Collections of data obtained from voluntary subjects. The information usually takes the form of answers to questions, or suggestions. Community Survey,Nonrespondent,Questionnaire,Questionnaires,Respondent,Survey,Survey Method,Survey Methods,Surveys,Baseline Survey,Community Surveys,Methodology, Survey,Nonrespondents,Questionnaire Design,Randomized Response Technique,Repeated Rounds of Survey,Respondents,Survey Methodology,Baseline Surveys,Design, Questionnaire,Designs, Questionnaire,Methods, Survey,Questionnaire Designs,Questionnaires and Surveys,Randomized Response Techniques,Response Technique, Randomized,Response Techniques, Randomized,Survey, Baseline,Survey, Community,Surveys, Baseline,Surveys, Community,Techniques, Randomized Response
D003865 Depressive Disorder, Major Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5) Depression, Involutional,Major Depressive Disorder,Melancholia, Involutional,Paraphrenia, Involutional,Psychosis, Involutional,Depressive Disorders, Major,Involutional Depression,Involutional Melancholia,Involutional Paraphrenia,Involutional Paraphrenias,Involutional Psychoses,Involutional Psychosis,Major Depressive Disorders,Paraphrenias, Involutional,Psychoses, Involutional
D005260 Female Females
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes
D006706 Homeostasis The processes whereby the internal environment of an organism tends to remain balanced and stable. Autoregulation
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

Richard J Porter, and Roger T Mulder, and Peter R Joyce, and Allison L Miller, and Martin Kennedy
June 2007, Journal of affective disorders,
Richard J Porter, and Roger T Mulder, and Peter R Joyce, and Allison L Miller, and Martin Kennedy
November 2021, BMC gastroenterology,
Richard J Porter, and Roger T Mulder, and Peter R Joyce, and Allison L Miller, and Martin Kennedy
March 2005, BMC medical genetics,
Richard J Porter, and Roger T Mulder, and Peter R Joyce, and Allison L Miller, and Martin Kennedy
September 2011, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry,
Richard J Porter, and Roger T Mulder, and Peter R Joyce, and Allison L Miller, and Martin Kennedy
November 2007, Neuroscience research,
Richard J Porter, and Roger T Mulder, and Peter R Joyce, and Allison L Miller, and Martin Kennedy
March 2010, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics,
Richard J Porter, and Roger T Mulder, and Peter R Joyce, and Allison L Miller, and Martin Kennedy
December 2010, Psychiatry research,
Richard J Porter, and Roger T Mulder, and Peter R Joyce, and Allison L Miller, and Martin Kennedy
July 2016, Cureus,
Richard J Porter, and Roger T Mulder, and Peter R Joyce, and Allison L Miller, and Martin Kennedy
August 2001, Psychiatry research,
Richard J Porter, and Roger T Mulder, and Peter R Joyce, and Allison L Miller, and Martin Kennedy
June 2009, Progress in neuro-psychopharmacology & biological psychiatry,
Copied contents to your clipboard!