-transparent.png){kind=logo}
Methylation of some genes is associated with tumoral progression in numerous cancers. The short arm of chromosome 11 is a hot spot for such methylations. The calcitonin gene (11p15) seems to be a good marker of these phenomenons, particularly in acute leukemias. The abnormal methylation pattern of the calcitonin gene in leukemic cells is visualized by Southern blotting after digestion of tumoral DNA with isoschizomeric restriction enzymes which are methylation sensitive or not. These studies seem of interest for acute myeloblastic leukemias (AML) where few molecular markers are available. Moreover hypermethylation of the calcitonin gene correlates with acceleration and transformation of chronic myeloid leukemia (CML). Sequential studies are warranted to evaluate if such techniques might help, especially for timing of bone marrow transplantation in CML.
A Baruchel, and
F Sigaux
June 1991,
Blood,
A Baruchel, and
F Sigaux
January 2001,
Voprosy meditsinskoi khimii,
A Baruchel, and
F Sigaux
February 1999,
Hematology and cell therapy,
A Baruchel, and
F Sigaux
February 1993,
Leukemia,
A Baruchel, and
F Sigaux
April 2001,
Zhonghua nei ke za zhi,
A Baruchel, and
F Sigaux
October 1995,
Leukemia research,
A Baruchel, and
F Sigaux
March 2001,
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao,
A Baruchel, and
F Sigaux
November 2007,
Leukemia,
A Baruchel, and
F Sigaux
March 2004,
Biochemistry. Biokhimiia,
A Baruchel, and
F Sigaux
July 2002,
Chinese medical journal,
