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The purpose of the study was the assessment of certain biological effects of semisynthetic human insulin compared with the presently used monocomponent preparations of porcine insulin made by the same producer. The study was carried out in a group of 10 healthy subjects (7 men and 3 women) twice: during a loading test with porcine insulin, and then during a similar test with human insulin. Both insulins were administered intravenously in doses of 0.075 units/kg body weight The physiological reactions associated with hypoglycaemia were noted, including subjective experiences and hormonal responses, among them those of glucagon, growth hormone, prolactin, adrenaline, noradrenaline and C-peptide. Semisynthetic human insulin administered intravenously was found to exert an identical hypoglycaemic effect as porcine insulin. However, it was observed that the action of porcine insulin was associated with more pronounced symptoms and more intense physiological reactions (tachycardia, body temperature fall) and a striking increase of prolactinaemia, in relation to semisynthetic human insulin.
M Stepka, and
H Rogala, and
A Kasperska-Dworak, and
B Wocial, and
W Jeske
March 1988,
Experimental and clinical endocrinology,
M Stepka, and
H Rogala, and
A Kasperska-Dworak, and
B Wocial, and
W Jeske
May 1987,
International journal of clinical pharmacology, therapy, and toxicology,
M Stepka, and
H Rogala, and
A Kasperska-Dworak, and
B Wocial, and
W Jeske
April 1986,
Australian and New Zealand journal of medicine,
M Stepka, and
H Rogala, and
A Kasperska-Dworak, and
B Wocial, and
W Jeske
October 1989,
Lancet (London, England),
M Stepka, and
H Rogala, and
A Kasperska-Dworak, and
B Wocial, and
W Jeske
November 1985,
Recenti progressi in medicina,
M Stepka, and
H Rogala, and
A Kasperska-Dworak, and
B Wocial, and
W Jeske
January 1985,
The Netherlands journal of medicine,
M Stepka, and
H Rogala, and
A Kasperska-Dworak, and
B Wocial, and
W Jeske
February 1984,
The Medical journal of Australia,
M Stepka, and
H Rogala, and
A Kasperska-Dworak, and
B Wocial, and
W Jeske
January 1983,
Diabetes care,
M Stepka, and
H Rogala, and
A Kasperska-Dworak, and
B Wocial, and
W Jeske
November 1989,
Ugeskrift for laeger,
M Stepka, and
H Rogala, and
A Kasperska-Dworak, and
B Wocial, and
W Jeske
June 1984,
Danish medical bulletin,
