BIOMAT Database Logo BIOMAT Database Logo

Pre-eclampsia is associated with airway hyperresponsiveness. 2008

S Siddiqui, and N Goodman, and S McKenna, and M Goldie, and J Waugh, and C E Brightling
Institute of Lung Health, University of Leicester, Leicester, UK.

Several large retrospective cohort studies demonstrate that pre-eclampsia is common in asthmatics. Whether airway hyperresponsiveness (AHR), a hallmark of asthma, is associated with pre-eclampsia is unknown. We measured AHR, using a methacholine challenge, and atopy in 19 women 3-60 months postpartum following pre-eclamptic or normotensive pregnancies. The geometric mean (95% CI) concentration of methacholine required to produce a >20% fall in the forced expiratory volume in 1 second (PC20 FEV1) was 8.9 (2.2-36) mg/ml in pre-eclamptics versus 72 (32-131) mg/ml in controls (P = 0.01) and 9 (1.9-40) mg/ml in atopic pre-eclamptics without asthma versus 54 (17-174) mg/ml (P = 0.038) in matched controls. Therefore, AHR was increased in women who have had pre-eclampsia. This association and its possible mechanisms warrant further investigation.

UI MeSH Term Description Entries
D011225 Pre-Eclampsia A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease. Toxemias, Pregnancy,EPH Complex,EPH Gestosis,EPH Toxemias,Edema-Proteinuria-Hypertension Gestosis,Gestosis, EPH,Hypertension-Edema-Proteinuria Gestosis,Preeclampsia,Preeclampsia Eclampsia 1,Pregnancy Toxemias,Proteinuria-Edema-Hypertension Gestosis,Toxemia Of Pregnancy,1, Preeclampsia Eclampsia,1s, Preeclampsia Eclampsia,EPH Toxemia,Eclampsia 1, Preeclampsia,Eclampsia 1s, Preeclampsia,Edema Proteinuria Hypertension Gestosis,Gestosis, Edema-Proteinuria-Hypertension,Gestosis, Hypertension-Edema-Proteinuria,Gestosis, Proteinuria-Edema-Hypertension,Hypertension Edema Proteinuria Gestosis,Of Pregnancies, Toxemia,Of Pregnancy, Toxemia,Pre Eclampsia,Preeclampsia Eclampsia 1s,Pregnancies, Toxemia Of,Pregnancy Toxemia,Pregnancy, Toxemia Of,Proteinuria Edema Hypertension Gestosis,Toxemia Of Pregnancies,Toxemia, EPH,Toxemia, Pregnancy,Toxemias, EPH
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D012130 Respiratory Hypersensitivity A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL. Airway Hyperresponsiveness,Hypersensitivity, Respiratory,Airway Hyper-Responsiveness,Airway Hyper Responsiveness,Airway Hyperresponsivenesses,Hyper-Responsiveness, Airway,Hyperresponsiveness, Airway,Respiratory Hypersensitivities
D005260 Female Females
D005541 Forced Expiratory Volume Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity. Forced Vital Capacity, Timed,Timed Vital Capacity,Vital Capacity, Timed,FEVt,Capacities, Timed Vital,Capacity, Timed Vital,Expiratory Volume, Forced,Expiratory Volumes, Forced,Forced Expiratory Volumes,Timed Vital Capacities,Vital Capacities, Timed,Volume, Forced Expiratory,Volumes, Forced Expiratory
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D016022 Case-Control Studies Comparisons that start with the identification of persons with the disease or outcome of interest and a control (comparison, referent) group without the disease or outcome of interest. The relationship of an attribute is examined by comparing both groups with regard to the frequency or levels of outcome over time. Case-Base Studies,Case-Comparison Studies,Case-Referent Studies,Matched Case-Control Studies,Nested Case-Control Studies,Case Control Studies,Case-Compeer Studies,Case-Referrent Studies,Case Base Studies,Case Comparison Studies,Case Control Study,Case Referent Studies,Case Referrent Studies,Case-Comparison Study,Case-Control Studies, Matched,Case-Control Studies, Nested,Case-Control Study,Case-Control Study, Matched,Case-Control Study, Nested,Case-Referent Study,Case-Referrent Study,Matched Case Control Studies,Matched Case-Control Study,Nested Case Control Studies,Nested Case-Control Study,Studies, Case Control,Studies, Case-Base,Studies, Case-Comparison,Studies, Case-Compeer,Studies, Case-Control,Studies, Case-Referent,Studies, Case-Referrent,Studies, Matched Case-Control,Studies, Nested Case-Control,Study, Case Control,Study, Case-Comparison,Study, Case-Control,Study, Case-Referent,Study, Case-Referrent,Study, Matched Case-Control,Study, Nested Case-Control
D016085 Bronchoconstrictor Agents Agents causing the narrowing of the lumen of a bronchus or bronchiole. Bronchial-Constricting Agents,Bronchoconstrictor Effect,Bronchoconstrictor Effects,Bronchoconstrictors,Agents, Bronchial-Constricting,Agents, Bronchoconstrictor,Bronchial Constricting Agents,Effect, Bronchoconstrictor,Effects, Bronchoconstrictor

Related Publications

S Siddiqui, and N Goodman, and S McKenna, and M Goldie, and J Waugh, and C E Brightling
Traffic-related air pollution is associated with airway hyperresponsiveness.
June 2014, The Journal of allergy and clinical immunology,
S Siddiqui, and N Goodman, and S McKenna, and M Goldie, and J Waugh, and C E Brightling
Atrial septal defect in adults is associated with airway hyperresponsiveness.
November 2018, Congenital heart disease,
S Siddiqui, and N Goodman, and S McKenna, and M Goldie, and J Waugh, and C E Brightling
Antigen-induced airway hyperresponsiveness is associated with airway tissue NEP hypoactivity in rats.
January 1994, Life sciences,
S Siddiqui, and N Goodman, and S McKenna, and M Goldie, and J Waugh, and C E Brightling
Small airway inflammation is associated with residual airway hyperresponsiveness in Th2-high asthma.
September 2020, The Journal of asthma : official journal of the Association for the Care of Asthma,
S Siddiqui, and N Goodman, and S McKenna, and M Goldie, and J Waugh, and C E Brightling
Prothrombin G20210A mutation: is it associated with pre-eclampsia?
January 2000, Gynecologic and obstetric investigation,
S Siddiqui, and N Goodman, and S McKenna, and M Goldie, and J Waugh, and C E Brightling
Low attenuation area is associated with airflow limitation and airway hyperresponsiveness.
November 2008, The Journal of asthma : official journal of the Association for the Care of Asthma,
S Siddiqui, and N Goodman, and S McKenna, and M Goldie, and J Waugh, and C E Brightling
Airway hyperresponsiveness is associated with airway remodeling but not inflammation in aging Cav1-/- mice.
October 2013, Respiratory research,
S Siddiqui, and N Goodman, and S McKenna, and M Goldie, and J Waugh, and C E Brightling
Endometriosis is associated with a decreased risk of pre-eclampsia.
June 2007, Human reproduction (Oxford, England),
S Siddiqui, and N Goodman, and S McKenna, and M Goldie, and J Waugh, and C E Brightling
Pre-eclampsia is associated with marked alterations in sleep architecture.
August 2000, Sleep,
S Siddiqui, and N Goodman, and S McKenna, and M Goldie, and J Waugh, and C E Brightling
Pre-eclampsia is associated with Helicobacter pylori seropositivity in Italy.
December 2006, Journal of hypertension,
Copied contents to your clipboard!