BIOMAT Database Logo BIOMAT Database Logo

Aging of the human corpus callosum: magnetic resonance imaging in normal volunteers. 1991

P M Doraiswamy, and G S Figiel, and M M Husain, and W M McDonald, and S A Shah, and O B Boyko, and E H Ellinwood, and K R Krishnan
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710.

A brain magnetic resonance imaging (MRI) study of the corpus callosum in 36 normal volunteers, ages 26-79 years, revealed that age was positively correlated with the T1 spin-lattice relaxation time of the corpus callosum and was negatively correlated with the corpus callosum cross-sectional area. T1 relaxation times are sensitive to the content and macromolecular environment of tissue water, and variations in callosal T1 may reflect differences in the content or relaxation properties of callosal water. Such changes also potentially could occur secondary to alterations in the composition of callosal myelin. This study confirms and extends prior morphological studies that have reported age-related dimensional changes in the corpus callosum and, in addition, provides evidence of age-related biophysical tissue differences in the human corpus callosum.

UI MeSH Term Description Entries
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D003337 Corpus Callosum Broad plate of dense myelinated fibers that reciprocally interconnect regions of the cortex in all lobes with corresponding regions of the opposite hemisphere. The corpus callosum is located deep in the longitudinal fissure. Interhemispheric Commissure,Neocortical Commissure,Callosum, Corpus,Callosums, Corpus,Commissure, Interhemispheric,Commissure, Neocortical,Commissures, Interhemispheric,Commissures, Neocortical,Corpus Callosums,Interhemispheric Commissures,Neocortical Commissures
D004292 Dominance, Cerebral Dominance of one cerebral hemisphere over the other in cerebral functions. Cerebral Dominance,Hemispheric Specialization,Dominances, Cerebral,Specialization, Hemispheric
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

P M Doraiswamy, and G S Figiel, and M M Husain, and W M McDonald, and S A Shah, and O B Boyko, and E H Ellinwood, and K R Krishnan
Human corpus callosum in aging and Alzheimer's disease: a magnetic resonance imaging study.
January 1994, Neurobiology of aging,
P M Doraiswamy, and G S Figiel, and M M Husain, and W M McDonald, and S A Shah, and O B Boyko, and E H Ellinwood, and K R Krishnan
Agenesis of the corpus callosum: magnetic resonance imaging.
May 1985, Radiology,
P M Doraiswamy, and G S Figiel, and M M Husain, and W M McDonald, and S A Shah, and O B Boyko, and E H Ellinwood, and K R Krishnan
Magnetic resonance imaging of the corpus callosum: predictors of size in normal adults.
January 1995, The Journal of neuropsychiatry and clinical neurosciences,
P M Doraiswamy, and G S Figiel, and M M Husain, and W M McDonald, and S A Shah, and O B Boyko, and E H Ellinwood, and K R Krishnan
[Magnetic resonance imaging in dysgenesis of the corpus callosum].
October 1985, Rinsho hoshasen. Clinical radiography,
P M Doraiswamy, and G S Figiel, and M M Husain, and W M McDonald, and S A Shah, and O B Boyko, and E H Ellinwood, and K R Krishnan
[Magnetic resonance imaging in agenesis of the corpus callosum].
December 1985, No to shinkei = Brain and nerve,
P M Doraiswamy, and G S Figiel, and M M Husain, and W M McDonald, and S A Shah, and O B Boyko, and E H Ellinwood, and K R Krishnan
Lipoma of the Corpus Callosum : Diagnosis Using Magnetic Resonance Imaging.
July 2006, Medical journal, Armed Forces India,
P M Doraiswamy, and G S Figiel, and M M Husain, and W M McDonald, and S A Shah, and O B Boyko, and E H Ellinwood, and K R Krishnan
Magnetic resonance imaging morphology of the corpus callosum in monozygotic twins.
July 1989, Annals of neurology,
P M Doraiswamy, and G S Figiel, and M M Husain, and W M McDonald, and S A Shah, and O B Boyko, and E H Ellinwood, and K R Krishnan
Corpus callosum size in schizophrenia--a magnetic resonance imaging analysis.
January 1999, European archives of psychiatry and clinical neuroscience,
P M Doraiswamy, and G S Figiel, and M M Husain, and W M McDonald, and S A Shah, and O B Boyko, and E H Ellinwood, and K R Krishnan
Sexual dimorphism and handedness in the human corpus callosum based on magnetic resonance imaging.
August 2005, Surgical and radiologic anatomy : SRA,
P M Doraiswamy, and G S Figiel, and M M Husain, and W M McDonald, and S A Shah, and O B Boyko, and E H Ellinwood, and K R Krishnan
Infarction of the corpus callosum: computed tomography and magnetic resonance imaging.
July 1997, European journal of radiology,
Copied contents to your clipboard!