Biomaterial Database

MDR1(ABCB1) gene polymorphisms associated with steroid-induced osteonecrosis of femoral head in systemic lupus erythematosus. 2007

X Y Yang, and D H Xu

Department of Rheumatology, The Second Affiliated Hospital, Zhejiang University, College of Medicine, Hangzhou, PR China.

This study investigated the relationship between genetic polymorphism in the MDR1 (C3435T, G2677T) and the development of steroid-induced osteonecrosis of femoral head (ONF) in Chinese systemic lupus erythematosus (SLE) patients. 127 patients with active SLE, receiving 40 mg/day or more prednisolone were included. Patients were observed for the development of ONF by magnetic resonance imaging (MRI) and plain radiography first at three months after the beginning of steroid treatment and subsequently every year for five years. Genomic DNA was obtained from peripheral blood lymphocytes. The MDR1 2677G > T and 3435C > T genotypes were determined by the PCR-RFLP assay. 21 patients developed steroid-induced ONF. The incidence of ONF was significantly higher in steroid pulse therapy. The MDR1 3435 TT genotypes were significantly lower in the incidence of ONF (adjusted odds ratio = 0.14, 95% CI 0.017-1.153, p = 0.038). The MDR1 2677 TT was also lower in the incidence of ONF (adjusted odds ratio = 0.21, 95% CI 0.018-1.301, p = 0.05). Our findings suggest that MDR1 (ABCB1) gene polymorphisms can be used for predicting the development of ONF.

UI	MeSH Term	Description	Entries
D008180	Lupus Erythematosus, Systemic	A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.	Libman-Sacks Disease,Lupus Erythematosus Disseminatus,Systemic Lupus Erythematosus,Disease, Libman-Sacks,Libman Sacks Disease
D008279	Magnetic Resonance Imaging	Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.	Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010020	Osteonecrosis	Death of a bone or part of a bone, either atraumatic or posttraumatic.	Aseptic Necrosis of Bone,Avascular Necrosis of Bone,Kienbock Disease,Necrosis, Aseptic, of Bone,Necrosis, Avascular, of Bone,Bone Necrosis,Kienbock's Disease,Kienboeck Disease,Kienboeck's Disease,Bone Aseptic Necrosis,Bone Avascular Necrosis,Bone Necroses,Kienboecks Disease,Necroses, Bone,Necrosis, Bone,Osteonecroses
D011110	Polymorphism, Genetic	The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.	Gene Polymorphism,Genetic Polymorphism,Polymorphism (Genetics),Genetic Polymorphisms,Gene Polymorphisms,Polymorphism, Gene,Polymorphisms (Genetics),Polymorphisms, Gene,Polymorphisms, Genetic
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D005260	Female		Females
D005270	Femur Head	The hemispheric articular surface at the upper extremity of the thigh bone. (Stedman, 26th ed)	Femoral Head,Femoral Heads,Femur Heads,Head, Femoral,Head, Femur
D005838	Genotype	The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.	Genogroup,Genogroups,Genotypes