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Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents. 2008
Chunhui Zhou, and
Jaeki Min, and
Zhigang Liu, and
Anne Young, and
Heather Deshazer, and
Tian Gao, and
Young-Tae Chang, and
Neville R Kallenbach
Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA.
Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity.
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