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[Preliminary experience with achieving immune tolerance in patients with hemophilia A and circulating factor VIII inhibitor]. 1991
R Scharf, and
W Kucharski, and
S Lopaciuk, and
W Celińska, and
A Dmytrow, and
K Domański, and
S Gonet, and
Z Miastkowski, and
I Nowakowska, and
A Przybylski
Klinika Chirurgiczna, Instytut Hematologii, Warszawa.
The appearance of antibodies to factor VIII is a serious complication in the treatment of haemophilia A. A protocol is presented aiming at suppression of the anticoagulant using continued treatment with factor VIII (25 u/kg b.w. twice weekly). Ten patients with previous maximal factor VIII antibody titre from 7 to 2900 Bethesda units were treated. So far the inhibitor was eradicated in 3 cases treated continuously for from 5 to 20 months. In two of these three cases successful surgical procedures were performed without anamnestic response.
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