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Discovery of novel FMS kinase inhibitors as anti-inflammatory agents. 2008
Carl R Illig, and
Jinsheng Chen, and
Mark J Wall, and
Kenneth J Wilson, and
Shelley K Ballentine, and
M Jonathan Rudolph, and
Renee L DesJarlais, and
Yanmin Chen, and
Carsten Schubert, and
Ioanna Petrounia, and
Carl S Crysler, and
Christopher J Molloy, and
Margery A Chaikin, and
Carl L Manthey, and
Mark R Player, and
Bruce E Tomczuk, and
Sanath K Meegalla
Johnson & Johnson Pharmaceutical Research & Development, Welsh & McKean Roads, Spring House, PA 19477, USA.
The optimization of the arylamide lead 2 resulted in identification of a highly potent series of 2,4-disubstituted arylamides. Compound 8 (FMS kinase IC(50)=0.0008 microM) served as a proof-of-concept candidate in a collagen-induced model of arthritis in mice.
Related Publications
Carl R Illig, and
Jinsheng Chen, and
Mark J Wall, and
Kenneth J Wilson, and
Shelley K Ballentine, and
M Jonathan Rudolph, and
Renee L DesJarlais, and
Yanmin Chen, and
Carsten Schubert, and
Ioanna Petrounia, and
Carl S Crysler, and
Christopher J Molloy, and
Margery A Chaikin, and
Carl L Manthey, and
Mark R Player, and
Bruce E Tomczuk, and
Sanath K Meegalla
June 2018,
European journal of medicinal chemistry,
Carl R Illig, and
Jinsheng Chen, and
Mark J Wall, and
Kenneth J Wilson, and
Shelley K Ballentine, and
M Jonathan Rudolph, and
Renee L DesJarlais, and
Yanmin Chen, and
Carsten Schubert, and
Ioanna Petrounia, and
Carl S Crysler, and
Christopher J Molloy, and
Margery A Chaikin, and
Carl L Manthey, and
Mark R Player, and
Bruce E Tomczuk, and
Sanath K Meegalla
March 2017,
Scientific reports,
Carl R Illig, and
Jinsheng Chen, and
Mark J Wall, and
Kenneth J Wilson, and
Shelley K Ballentine, and
M Jonathan Rudolph, and
Renee L DesJarlais, and
Yanmin Chen, and
Carsten Schubert, and
Ioanna Petrounia, and
Carl S Crysler, and
Christopher J Molloy, and
Margery A Chaikin, and
Carl L Manthey, and
Mark R Player, and
Bruce E Tomczuk, and
Sanath K Meegalla
September 2015,
European journal of medicinal chemistry,
Carl R Illig, and
Jinsheng Chen, and
Mark J Wall, and
Kenneth J Wilson, and
Shelley K Ballentine, and
M Jonathan Rudolph, and
Renee L DesJarlais, and
Yanmin Chen, and
Carsten Schubert, and
Ioanna Petrounia, and
Carl S Crysler, and
Christopher J Molloy, and
Margery A Chaikin, and
Carl L Manthey, and
Mark R Player, and
Bruce E Tomczuk, and
Sanath K Meegalla
December 2013,
Mini reviews in medicinal chemistry,
Carl R Illig, and
Jinsheng Chen, and
Mark J Wall, and
Kenneth J Wilson, and
Shelley K Ballentine, and
M Jonathan Rudolph, and
Renee L DesJarlais, and
Yanmin Chen, and
Carsten Schubert, and
Ioanna Petrounia, and
Carl S Crysler, and
Christopher J Molloy, and
Margery A Chaikin, and
Carl L Manthey, and
Mark R Player, and
Bruce E Tomczuk, and
Sanath K Meegalla
November 2006,
Current opinion in investigational drugs (London, England : 2000),
Carl R Illig, and
Jinsheng Chen, and
Mark J Wall, and
Kenneth J Wilson, and
Shelley K Ballentine, and
M Jonathan Rudolph, and
Renee L DesJarlais, and
Yanmin Chen, and
Carsten Schubert, and
Ioanna Petrounia, and
Carl S Crysler, and
Christopher J Molloy, and
Margery A Chaikin, and
Carl L Manthey, and
Mark R Player, and
Bruce E Tomczuk, and
Sanath K Meegalla
August 1999,
Current opinion in chemical biology,
Carl R Illig, and
Jinsheng Chen, and
Mark J Wall, and
Kenneth J Wilson, and
Shelley K Ballentine, and
M Jonathan Rudolph, and
Renee L DesJarlais, and
Yanmin Chen, and
Carsten Schubert, and
Ioanna Petrounia, and
Carl S Crysler, and
Christopher J Molloy, and
Margery A Chaikin, and
Carl L Manthey, and
Mark R Player, and
Bruce E Tomczuk, and
Sanath K Meegalla
May 2016,
European journal of medicinal chemistry,
Carl R Illig, and
Jinsheng Chen, and
Mark J Wall, and
Kenneth J Wilson, and
Shelley K Ballentine, and
M Jonathan Rudolph, and
Renee L DesJarlais, and
Yanmin Chen, and
Carsten Schubert, and
Ioanna Petrounia, and
Carl S Crysler, and
Christopher J Molloy, and
Margery A Chaikin, and
Carl L Manthey, and
Mark R Player, and
Bruce E Tomczuk, and
Sanath K Meegalla
January 2023,
Medicinal chemistry (Shariqah (United Arab Emirates)),
Carl R Illig, and
Jinsheng Chen, and
Mark J Wall, and
Kenneth J Wilson, and
Shelley K Ballentine, and
M Jonathan Rudolph, and
Renee L DesJarlais, and
Yanmin Chen, and
Carsten Schubert, and
Ioanna Petrounia, and
Carl S Crysler, and
Christopher J Molloy, and
Margery A Chaikin, and
Carl L Manthey, and
Mark R Player, and
Bruce E Tomczuk, and
Sanath K Meegalla
May 2017,
Expert opinion on therapeutic patents,
Carl R Illig, and
Jinsheng Chen, and
Mark J Wall, and
Kenneth J Wilson, and
Shelley K Ballentine, and
M Jonathan Rudolph, and
Renee L DesJarlais, and
Yanmin Chen, and
Carsten Schubert, and
Ioanna Petrounia, and
Carl S Crysler, and
Christopher J Molloy, and
Margery A Chaikin, and
Carl L Manthey, and
Mark R Player, and
Bruce E Tomczuk, and
Sanath K Meegalla
April 2007,
British journal of pharmacology,
