Di(2-ethylhexyl) phthalate exposure during cardiopulmonary bypass. 2008

Yosuke Takahashi, and Toshihiko Shibata, and Yasuyuki Sasaki, and Hiromichi Fujii, and Yasuyuki Bito, and Shigefumi Suehiro
Department of Cardiovascular Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Osaka 545-8585, Japan. ysk@msic.med.osaka-cu.ac.jp

Di(2-ethylhexyl) phthalate is an excellent plasticizer for polyvinyl chloride but a known endocrine disrupting chemical. To investigate whether tubing containing no diethylhexyl phthalate reduces the overall extraction of this plasticizer during cardiopulmonary bypass, 16 patients undergoing coronary artery bypass grafting were randomly divided into 2 groups of 8 each. Group A had tubing containing diethylhexyl phthalate in the circuit, and group B had no diethylhexyl phthalate in the tubing. The plasma diethylhexyl phthalate level at the end of cardiopulmonary bypass was significantly increased compared to before anesthesia in both groups (group A: 103 +/- 60 to 2,094 +/- 1,046 ng x mL(-1); group B: 135 +/- 60 to 472 +/- 141 ng x mL(-1)), and it was significantly higher in group A than group B. This study demonstrates that using tubing free from diethylhexyl phthalate significantly reduces the release of this agent during cardiopulmonary bypass, which may minimize exposure to diethylhexyl phthalate.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010968 Plasticizers Materials incorporated mechanically in plastics (usually PVC) to increase flexibility, workability or distensibility; due to the non-chemical inclusion, plasticizers leach out from the plastic and are found in body fluids and the general environment. Plasticizer
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D002315 Cardiopulmonary Bypass Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs. Heart-Lung Bypass,Bypass, Cardiopulmonary,Bypass, Heart-Lung,Bypasses, Cardiopulmonary,Bypasses, Heart-Lung,Cardiopulmonary Bypasses,Heart Lung Bypass,Heart-Lung Bypasses
D004051 Diethylhexyl Phthalate An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers. Dioctyl Phthalate,Bis(2-ethylhexyl)phthalate,DEHP,Di(2-ethylhexyl)phthalate,Di-2-Ethylhexylphthalate,Di 2 Ethylhexylphthalate,Phthalate, Diethylhexyl,Phthalate, Dioctyl
D004867 Equipment Design Methods and patterns of fabricating machines and related hardware. Design, Equipment,Device Design,Medical Device Design,Design, Medical Device,Designs, Medical Device,Device Design, Medical,Device Designs, Medical,Medical Device Designs,Design, Device,Designs, Device,Designs, Equipment,Device Designs,Equipment Designs
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D001026 Coronary Artery Bypass Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion. Aortocoronary Bypass,Bypass, Coronary Artery,Bypass Surgery, Coronary Artery,Coronary Artery Bypass Grafting,Coronary Artery Bypass Surgery,Aortocoronary Bypasses,Artery Bypass, Coronary,Artery Bypasses, Coronary,Bypass, Aortocoronary,Bypasses, Aortocoronary,Bypasses, Coronary Artery,Coronary Artery Bypasses

Related Publications

Yosuke Takahashi, and Toshihiko Shibata, and Yasuyuki Sasaki, and Hiromichi Fujii, and Yasuyuki Bito, and Shigefumi Suehiro
June 2001, Kyobu geka. The Japanese journal of thoracic surgery,
Yosuke Takahashi, and Toshihiko Shibata, and Yasuyuki Sasaki, and Hiromichi Fujii, and Yasuyuki Bito, and Shigefumi Suehiro
January 2004, Report on carcinogens : carcinogen profiles,
Yosuke Takahashi, and Toshihiko Shibata, and Yasuyuki Sasaki, and Hiromichi Fujii, and Yasuyuki Bito, and Shigefumi Suehiro
April 1989, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Yosuke Takahashi, and Toshihiko Shibata, and Yasuyuki Sasaki, and Hiromichi Fujii, and Yasuyuki Bito, and Shigefumi Suehiro
January 2011, Report on carcinogens : carcinogen profiles,
Yosuke Takahashi, and Toshihiko Shibata, and Yasuyuki Sasaki, and Hiromichi Fujii, and Yasuyuki Bito, and Shigefumi Suehiro
January 2000, IARC monographs on the evaluation of carcinogenic risks to humans,
Yosuke Takahashi, and Toshihiko Shibata, and Yasuyuki Sasaki, and Hiromichi Fujii, and Yasuyuki Bito, and Shigefumi Suehiro
January 2002, Report on carcinogens : carcinogen profiles,
Yosuke Takahashi, and Toshihiko Shibata, and Yasuyuki Sasaki, and Hiromichi Fujii, and Yasuyuki Bito, and Shigefumi Suehiro
May 1982, IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans,
Yosuke Takahashi, and Toshihiko Shibata, and Yasuyuki Sasaki, and Hiromichi Fujii, and Yasuyuki Bito, and Shigefumi Suehiro
August 2003, Transfusion,
Yosuke Takahashi, and Toshihiko Shibata, and Yasuyuki Sasaki, and Hiromichi Fujii, and Yasuyuki Bito, and Shigefumi Suehiro
November 2022, Acta Cardiologica Sinica,
Yosuke Takahashi, and Toshihiko Shibata, and Yasuyuki Sasaki, and Hiromichi Fujii, and Yasuyuki Bito, and Shigefumi Suehiro
March 1999, International journal of pharmaceutics,
Copied contents to your clipboard!