In this study, three separate experiments were carried out to explore the potential of Epipremnum plants for Co-60 and Cs-137 uptake and rhizofiltration from solutions. Experiment I was carried out to screen the effects of different concentration (0-10 mM) of stable Co and Cs salts on some physiological components of the Epipremnum over 20 d. Data from the experiment showed that 1 mM of either Co or Cs had no adverse effects on the chlorophyll, soluble sugar, and protein of Epipremnum. Over 20 d at a high concentration (10 mM), some effects of Co or Cs were detectable but were not inhibitory. Experiment H showed an increase in the concentration ratios (CRs) of carrier-free Co-60 and Cs-137 relative to their concentration in the solution. Transport indexes (TIs) of Co-60 only increased with increasing its concentration in the solution. CRs increased with time and more than 50% of Co-60 and Cs-137 was detected at 5 d. Based on the data obtained from experiments I and II, both stable Co and Cs were used as carriers for Co-60 and Cs-137 to study their uptake and translocation in Experiment III. It was found that the Epipremnum plant had bioconcentration factors (BCFs) of 10.69 and 2.26 for Co and Cs, respectively. However, TI was 13.8 for Co and 35.6 for Cs. The accumulation of Co-60 and Cs-137 in the roots of Epipremnum might offer a method for Co-60 and Cs-137 rhizofiltration.