[Nasal allergen provocation test, allergic skin tests and serum allergen-specific IgE level in asthmatic children]. 2007

Andrzej Emeryk, and Małgorzata Bartkowiak-Emeryk
Klinika Chorób Płuc i Reumatologii, Akademii Medycznej w Lublinie.

BACKGROUND The important element in the asthma diagnosis is a confirmation of trigger's asthma symptoms allergens. OBJECTIVE The aim of this study was to evaluate diagnostic value of an allergic skin prick test and serum allergen-specific IgE level with reference to nasal allergen provocation test (NPT) results in asthmatic children. METHODS Study was performed in 80 asthmatic children in 3-14 yrs aged. 118 NPTs accompanied by assessments of nasal airflow by rhinospirography, were done. In all subjects, allergic skin prick tests with mites and grasses or trees pollen allergens and serum allergen specific IgE levels with the allergen used in NPT were done. RESULTS Concordance between SPT and TPN results was shown in 59% cases, most often in group with pollen than mites provocation. SPT's sensitivity and specificity in relation to TPN result was 71% and 53%, respectively. Concordance between asIgE level and TPN results was shown in 76% cases. asIgE results sensitivity and specificity in relation to TPN result was 71% and 82%, respectively. CONCLUSIONS The usefulness of skin prick test results in allergologic diagnosis of asthma is lesser than serum allergen specific IgE determination, especially in patients with house dust mites allergens hypersensitivity. Nasal provocation test (NPT) with suspected allergen should be performed in asthmatic children with a negative or doubtful skin prick test or serum allergen specific IgE level results.

UI MeSH Term Description Entries
D007073 Immunoglobulin E An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE). IgE
D008297 Male Males
D009299 Nasal Provocation Tests Application of allergens to the nasal mucosa. Interpretation includes observation of nasal symptoms, rhinoscopy, and rhinomanometry. Nasal provocation tests are used in the diagnosis of nasal hypersensitivity, including RHINITIS, ALLERGIC, SEASONAL. Provocation Tests, Nasal,Nasal Provocation Test,Provocation Test, Nasal,Test, Nasal Provocation,Tests, Nasal Provocation
D011237 Predictive Value of Tests In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test. Negative Predictive Value,Positive Predictive Value,Predictive Value Of Test,Predictive Values Of Tests,Negative Predictive Values,Positive Predictive Values,Predictive Value, Negative,Predictive Value, Positive
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D001249 Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). Asthma, Bronchial,Bronchial Asthma,Asthmas

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