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The activity of oxytetracycline and seven macrolide antibiotics was investigated against a prototype strain of Chlamydia pneumoniae in cell culture. Following incubation, inoculated cell monolayers were fixed in methanol and stained with a genus specific immunofluorescent monoclonal antibody before examination for inhibition of inclusion formation. The most active agent was clarithromycin (MIC 0.007 mg/l), followed by erythromycin (0.06 mg/l). Other macrolides were less active; josamycin and roxithromycin (0.25 mg/l), midecamycin acetate and azithromycin (0.5 mg/l) and spiramycin (4.0 mg/l). The MIC of oxytetracycline was 0.25 mg/l. Clinical evaluation of clarithromycin for C. pneumoniae lower respiratory infection is indicated.
G L Ridgway, and
G Mumtaz, and
L Fenelon
September 1989,
Antimicrobial agents and chemotherapy,
G L Ridgway, and
G Mumtaz, and
L Fenelon
January 1992,
Annual review of medicine,
G L Ridgway, and
G Mumtaz, and
L Fenelon
December 1993,
European heart journal,
G L Ridgway, and
G Mumtaz, and
L Fenelon
January 1991,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
G L Ridgway, and
G Mumtaz, and
L Fenelon
June 1991,
Clinics in chest medicine,
G L Ridgway, and
G Mumtaz, and
L Fenelon
November 1996,
Antimicrobial agents and chemotherapy,
G L Ridgway, and
G Mumtaz, and
L Fenelon
November 1993,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
G L Ridgway, and
G Mumtaz, and
L Fenelon
November 1992,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
G L Ridgway, and
G Mumtaz, and
L Fenelon
October 1995,
Clinical microbiology reviews,
