-transparent.png){kind=logo}
We studied the lymphocyte proliferative response to Chlamydia trachomatis in Reiter's syndrome (RS) compared with that in other rheumatic diseases. RS patients showed significantly increased C trachomatis-specific synovial fluid (SF) T cell proliferation. Proliferating cells were found in both CD4+ and CD8+ T cell subsets. The SF lymphocyte proliferative response to C trachomatis in RS was inhibited by anti-class I and class II major histocompatibility complex monoclonal antibodies, while the response to tuberculin purified protein derivative was inhibited only by anti-class II monoclonal antibodies. T cell receptor gamma/delta-bearing T cells were not consistently increased in RS SF compared with peripheral blood, nor did such cells consistently expand upon in vitro culture with C trachomatis. Finally, there was no correlation between the cellular immune response and levels of antibody to C trachomatis antigens. Our results indicate that a specific T cell response to C trachomatis within the joint plays a role in the pathogenesis of RS.
J Sieper, and
G Kingsley, and
A Palacios-Boix, and
C Pitzalis, and
J Treharne, and
R Hughes, and
A Keat, and
G S Panayi
August 1992,
The Journal of rheumatology,
J Sieper, and
G Kingsley, and
A Palacios-Boix, and
C Pitzalis, and
J Treharne, and
R Hughes, and
A Keat, and
G S Panayi
August 1987,
Clinical and experimental immunology,
J Sieper, and
G Kingsley, and
A Palacios-Boix, and
C Pitzalis, and
J Treharne, and
R Hughes, and
A Keat, and
G S Panayi
January 1993,
Vojnosanitetski pregled,
J Sieper, and
G Kingsley, and
A Palacios-Boix, and
C Pitzalis, and
J Treharne, and
R Hughes, and
A Keat, and
G S Panayi
October 1983,
Scandinavian journal of immunology,
J Sieper, and
G Kingsley, and
A Palacios-Boix, and
C Pitzalis, and
J Treharne, and
R Hughes, and
A Keat, and
G S Panayi
January 1986,
Annali Sclavo. Collana monografica,
J Sieper, and
G Kingsley, and
A Palacios-Boix, and
C Pitzalis, and
J Treharne, and
R Hughes, and
A Keat, and
G S Panayi
January 1990,
Vestnik dermatologii i venerologii,
J Sieper, and
G Kingsley, and
A Palacios-Boix, and
C Pitzalis, and
J Treharne, and
R Hughes, and
A Keat, and
G S Panayi
February 1984,
Annals of internal medicine,
J Sieper, and
G Kingsley, and
A Palacios-Boix, and
C Pitzalis, and
J Treharne, and
R Hughes, and
A Keat, and
G S Panayi
January 1985,
Reviews of infectious diseases,
J Sieper, and
G Kingsley, and
A Palacios-Boix, and
C Pitzalis, and
J Treharne, and
R Hughes, and
A Keat, and
G S Panayi
November 2004,
Journal of immunology (Baltimore, Md. : 1950),
J Sieper, and
G Kingsley, and
A Palacios-Boix, and
C Pitzalis, and
J Treharne, and
R Hughes, and
A Keat, and
G S Panayi
January 2003,
Vojnosanitetski pregled,
