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In this paper the results of investigations on the effect of interferon-alpha (IFN-alpha) on the growth of meningioma cells in culture is reported. A consecutive series of six meningiomas and one meningioma/neurofibroma derived from a patient with neurofibromatosis type 2 was investigated and it was found that the growth of all seven tumours in response to mitotic stimuli (fetal bovine serum or epidermal growth factor) is strongly inhibited by IFN-alpha. Maximal response varied between 100% and 70% inhibition of the incorporation of tritiated thymidine. In some cases an inhibitory response was obtained already at very low doses (less than or equal to 10 U of IFN-alpha per ml). These results indicate that further clinical investigation of the application of IFN-alpha to the treatment of meningioma is warranted.
J W Koper, and
E C Zwarthoff, and
A Hagemeijer, and
R Braakman, and
C J Avezaat, and
M Bergström, and
S W Lamberts
August 1994,
Tumori,
J W Koper, and
E C Zwarthoff, and
A Hagemeijer, and
R Braakman, and
C J Avezaat, and
M Bergström, and
S W Lamberts
May 1984,
Infection and immunity,
J W Koper, and
E C Zwarthoff, and
A Hagemeijer, and
R Braakman, and
C J Avezaat, and
M Bergström, and
S W Lamberts
January 1983,
Journal of interferon research,
J W Koper, and
E C Zwarthoff, and
A Hagemeijer, and
R Braakman, and
C J Avezaat, and
M Bergström, and
S W Lamberts
October 1983,
Gan,
J W Koper, and
E C Zwarthoff, and
A Hagemeijer, and
R Braakman, and
C J Avezaat, and
M Bergström, and
S W Lamberts
February 1987,
Journal of cellular physiology,
J W Koper, and
E C Zwarthoff, and
A Hagemeijer, and
R Braakman, and
C J Avezaat, and
M Bergström, and
S W Lamberts
October 1976,
Acta pathologica et microbiologica Scandinavica. Section B, Microbiology,
J W Koper, and
E C Zwarthoff, and
A Hagemeijer, and
R Braakman, and
C J Avezaat, and
M Bergström, and
S W Lamberts
January 1996,
Anticancer research,
J W Koper, and
E C Zwarthoff, and
A Hagemeijer, and
R Braakman, and
C J Avezaat, and
M Bergström, and
S W Lamberts
June 1990,
Infection and immunity,
J W Koper, and
E C Zwarthoff, and
A Hagemeijer, and
R Braakman, and
C J Avezaat, and
M Bergström, and
S W Lamberts
August 1989,
The British journal of dermatology,
J W Koper, and
E C Zwarthoff, and
A Hagemeijer, and
R Braakman, and
C J Avezaat, and
M Bergström, and
S W Lamberts
January 1984,
Journal of interferon research,
