Biomaterial Database

Bioavailability of fluoride from dietary sepiolite in the lamb. 1991

A Chaso, and R Pascual, and J A Madrid, and G M Salido

Facultad de Veterinaria, Departamento de Zootecnia, Caceres, Spain.

Nine weeks after weaning, 12 lambs were randomised to 2 groups, each consisting of 6 animals. One group received a diet containing 213.9 mg/kg of fluor (F) in the form of sodium fluoride (NaF) and the other group received a diet containing 212.3 mg/kg of fluor in the form of sepiolite. The 24 h time courses of plasma fluoride concentrations showed that after feeding the average peak plasma concentration of the NaF-fed group was 0.75 microgram F/ml; that of the sepiolite-fed group was 0.35 microgram F/ml. The 12-h area under the plasma concentration curve (AUC) values in the NaF-fed group were higher with statistical significance (P less than 0.001) at each time point. Compared with fluoride from NaF, the relative bioavailability of fluoride from sepiolite was found to be very weak.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008903	Minerals	Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	Mineral
D005459	Fluorides	Inorganic salts of hydrofluoric acid, HF, in which the fluorine atom is in the -1 oxidation state. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Sodium and stannous salts are commonly used in dentifrices.	Fluoride
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000821	Animal Feed	Foodstuff used especially for domestic and laboratory animals, or livestock.	Fodder,Animal Feeds,Feed, Animal,Feeds, Animal,Fodders
D001682	Biological Availability	The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.	Availability Equivalency,Bioavailability,Physiologic Availability,Availability, Biologic,Availability, Biological,Availability, Physiologic,Biologic Availability,Availabilities, Biologic,Availabilities, Biological,Availabilities, Physiologic,Availability Equivalencies,Bioavailabilities,Biologic Availabilities,Biological Availabilities,Equivalencies, Availability,Equivalency, Availability,Physiologic Availabilities
D012756	Sheep	Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.	Ovis,Sheep, Dall,Dall Sheep,Ovis dalli
D012969	Sodium Fluoride	A source of inorganic fluoride which is used topically to prevent dental caries.	Fluoristat,Ossin,Zymafluor,Fluoride, Sodium,Fluorides, Sodium,Fluoristats,Ossins,Sodium Fluorides,Zymafluors
D017633	Magnesium Silicates	A generic term for a variety of compounds that contain silicon, oxygen, and magnesium, and may contain hydrogen. Examples include TALC and some kinds of ASBESTOS.	Silicates, Magnesium