BIOMAT Database Logo BIOMAT Database Logo

Responses of atrial natriuretic peptide, vasopressin, aldosterone and renal function to intracerebroventricular infusion of angiotensin II in dogs. 1991

M Shoji, and T Kimura, and K Ota, and M Inoue, and K Sato, and M Ohta, and T Yamamoto, and K Abe, and K Yoshinaga
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.

To assess the mechanisms how angiotensin II (Ang II) given intracerebroventricularly (i.c.v.) induces natriuresis, the effects of Ang II (10 ng/kg/min, for 30 min) on the renin-angiotensin-aldosterone system, the release of vasopressin (AVP) and atrial natriuretic peptide (ANP) and on cardiovascular and renal functions were investigated in anesthetized dogs. In control dogs, vehicle alone (artificial cerebrospinal fluid) was infused at a rate of 10 microliters/min. Ang II given i.c.v. produced a gradual increase in urine flow, urinary sodium and potassium excretion and osmolar clearance, but had no effect on plasma ANP, aldosterone, arterial blood pressure, and renal blood flow. However, i.c.v. Ang II increased plasma AVP and decreased heart rate, plasma renin activity, inulin clearance and filtration fraction. In the cotrol group, vehicle treatment had no effect on these parameters except for decreases in inulin clearance and filtration fraction. These results suggest that circulating ANP and blood pressure may not play an important role in i.c.v. Ang II-induced natriuresis, but increased AVP release and decreased renal sympathetic nervous activity may contribute to the natriuresis.

UI MeSH Term Description Entries
D007276 Injections, Intraventricular Injections into the cerebral ventricles. Intraventricular Injections,Injection, Intraventricular,Intraventricular Injection
D007668 Kidney Body organ that filters blood for the secretion of URINE and that regulates ion concentrations. Kidneys
D008297 Male Males
D009318 Natriuresis Sodium excretion by URINATION. Natriureses
D009320 Atrial Natriuretic Factor A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS. ANF,ANP,Atrial Natriuretic Peptide,Atrial Natriuretic Peptides,Atriopeptins,Auriculin,Natriuretic Peptides, Atrial,ANF (1-126),ANF (1-28),ANF (99-126),ANF Precursors,ANP (1-126),ANP (1-28),ANP Prohormone (99-126),ANP-(99-126),Atrial Natriuretic Factor (1-126),Atrial Natriuretic Factor (1-28),Atrial Natriuretic Factor (99-126),Atrial Natriuretic Factor Precursors,Atrial Natriuretic Factor Prohormone,Atrial Natriuretic Peptide (1-126),Atrial Pronatriodilatin,Atriopeptigen,Atriopeptin (1-28),Atriopeptin (99-126),Atriopeptin 126,Atriopeptin Prohormone (1-126),Cardiodilatin (99-126),Cardiodilatin Precursor,Cardionatrin I,Cardionatrin IV,Prepro-ANP,Prepro-CDD-ANF,Prepro-Cardiodilatin-Atrial Natriuretic Factor,Pro-ANF,ProANF,Proatrial Natriuretic Factor,Pronatriodilatin,alpha ANP,alpha-ANP Dimer,alpha-Atrial Natriuretic Peptide,beta-ANP,beta-Atrial Natriuretic Peptide,gamma ANP (99-126),gamma-Atrial Natriuretic Peptide,Natriuretic Peptide, Atrial,Peptide, Atrial Natriuretic,Peptides, Atrial Natriuretic,Prepro ANP,Prepro CDD ANF,Prepro Cardiodilatin Atrial Natriuretic Factor,Pro ANF,alpha ANP Dimer,alpha Atrial Natriuretic Peptide,beta ANP,beta Atrial Natriuretic Peptide,gamma Atrial Natriuretic Peptide
D012083 Renin A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19. Angiotensin-Forming Enzyme,Angiotensinogenase,Big Renin,Cryorenin,Inactive Renin,Pre-Prorenin,Preprorenin,Prorenin,Angiotensin Forming Enzyme,Pre Prorenin,Renin, Big,Renin, Inactive
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D005260 Female Females
D000450 Aldosterone A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. Aldosterone, (+-)-Isomer,Aldosterone, (11 beta,17 alpha)-Isomer
D000804 Angiotensin II An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS. Angiotensin II, Ile(5)-,Angiotensin II, Val(5)-,5-L-Isoleucine Angiotensin II,ANG-(1-8)Octapeptide,Angiotensin II, Isoleucine(5)-,Angiotensin II, Valine(5)-,Angiotensin-(1-8) Octapeptide,Isoleucine(5)-Angiotensin,Isoleucyl(5)-Angiotensin II,Valyl(5)-Angiotensin II,5 L Isoleucine Angiotensin II,Angiotensin II, 5-L-Isoleucine

Related Publications

M Shoji, and T Kimura, and K Ota, and M Inoue, and K Sato, and M Ohta, and T Yamamoto, and K Abe, and K Yoshinaga
Intracerebroventricular atrial natriuretic peptide infusion augments the adrenocorticotropin and angiotensin II responses to hemorrhage in sheep.
December 1990, Neuroendocrinology,
M Shoji, and T Kimura, and K Ota, and M Inoue, and K Sato, and M Ohta, and T Yamamoto, and K Abe, and K Yoshinaga
Atrial natriuretic peptide and vasopressin during percutaneous transvenous mitral valvuloplasty and relation to renin-angiotensin-aldosterone system and renal function.
April 1990, The American journal of cardiology,
M Shoji, and T Kimura, and K Ota, and M Inoue, and K Sato, and M Ohta, and T Yamamoto, and K Abe, and K Yoshinaga
Comparative effects of atrial natriuretic peptide and brain natriuretic peptide on the aldosterone and pressor responses to angiotensin II in man.
January 1995, Clinical science (London, England : 1979),
M Shoji, and T Kimura, and K Ota, and M Inoue, and K Sato, and M Ohta, and T Yamamoto, and K Abe, and K Yoshinaga
Verapamil sustained-release in renal parenchymal hypertension: effect on blood pressure, kidney function, angiotensin II, aldosterone, arginine vasopressin, atrial natriuretic peptide, and lipoproteins.
January 1989, Journal of cardiovascular pharmacology,
M Shoji, and T Kimura, and K Ota, and M Inoue, and K Sato, and M Ohta, and T Yamamoto, and K Abe, and K Yoshinaga
Atrial natriuretic peptide counteracts angiotensin-II-induced impairment of renal function.
January 1988, Zeitschrift fur Kardiologie,
M Shoji, and T Kimura, and K Ota, and M Inoue, and K Sato, and M Ohta, and T Yamamoto, and K Abe, and K Yoshinaga
Intracerebroventricular infusion of angiotensin II inhibits aldosterone secretion.
December 1980, The American journal of physiology,
M Shoji, and T Kimura, and K Ota, and M Inoue, and K Sato, and M Ohta, and T Yamamoto, and K Abe, and K Yoshinaga
Atrial natriuretic peptide inhibits the aldosterone response to angiotensin II in man.
May 1986, Clinical science (London, England : 1979),
M Shoji, and T Kimura, and K Ota, and M Inoue, and K Sato, and M Ohta, and T Yamamoto, and K Abe, and K Yoshinaga
Renal responses to intracerebroventricular infusions of atrial natriuretic peptide in the conscious goat.
January 1988, Acta physiologica Scandinavica,
M Shoji, and T Kimura, and K Ota, and M Inoue, and K Sato, and M Ohta, and T Yamamoto, and K Abe, and K Yoshinaga
Atrial natriuretic peptide suppresses renal vasoconstriction induced by angiotensin II and norepinephrine in dogs.
November 1992, European journal of pharmacology,
M Shoji, and T Kimura, and K Ota, and M Inoue, and K Sato, and M Ohta, and T Yamamoto, and K Abe, and K Yoshinaga
Fetal and maternal plasma atrial natriuretic factor responses to angiotensin II infusion.
December 1991, American journal of obstetrics and gynecology,
Copied contents to your clipboard!