BIOMAT Database Logo BIOMAT Database Logo

Long-term follow-up of non-seminomatous testicular cancer patients with mature teratoma or carcinoma at postchemotherapy surgery. EORTC Genitourinary Tract Cancer Cooperative Group (EORTC GU Group) 1991

R L Jansen, and R Sylvester, and D T Sleyfer, and W W ten Bokkel Huinink, and S B Kaye, and W G Jones, and J Keizer, and A T van Oosterom, and S Meyer, and C P Vendrik
Department of Medical Oncology, Rotterdam Cancer Institute, Rotterdam, The Netherlands.

From 1979 to 1983 the EORTC GU Group treated 239 patients with disseminated non-seminomatous testicular cancer with combination chemotherapy comprising cisplatin, vinblastine and bleomycin in a prospectively controlled trial. The protocol required complete resection of residual masses after induction chemotherapy, provided that serum tumour markers were normal. 102 patients were operated on. 27 patients had mature teratoma (teratoma differentiated) in the resected specimens and 23 had viable cancer. Follow-up data were available for 26 and 22 of these patients, respectively. 23 of 26 patients (88%) with mature teratoma are alive and disease free after a follow-up of 53-110 months (median 92 months). 3 patients developed progressive disease; 1 died. A peculiar case of growing mature teratoma on the forearm is described. 13 of 22 patients (59%) with residual carcinoma are alive and disease free after a follow-up of 74-112 months (median 95 months). The prognosis of patients with carcinoma is shown to be correlated with the completeness of surgery, which in turn is correlated with the initial tumour mass before chemotherapy.

UI MeSH Term Description Entries
D008297 Male Males
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D002277 Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for "cancer." Carcinoma, Anaplastic,Carcinoma, Spindle-Cell,Carcinoma, Undifferentiated,Carcinomatosis,Epithelial Neoplasms, Malignant,Epithelioma,Epithelial Tumors, Malignant,Malignant Epithelial Neoplasms,Neoplasms, Malignant Epithelial,Anaplastic Carcinoma,Anaplastic Carcinomas,Carcinoma, Spindle Cell,Carcinomas,Carcinomatoses,Epithelial Neoplasm, Malignant,Epithelial Tumor, Malignant,Epitheliomas,Malignant Epithelial Neoplasm,Malignant Epithelial Tumor,Malignant Epithelial Tumors,Neoplasm, Malignant Epithelial,Spindle-Cell Carcinoma,Spindle-Cell Carcinomas,Tumor, Malignant Epithelial,Undifferentiated Carcinoma,Undifferentiated Carcinomas
D003131 Combined Modality Therapy The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used. Multimodal Treatment,Therapy, Combined Modality,Combined Modality Therapies,Modality Therapies, Combined,Modality Therapy, Combined,Multimodal Treatments,Therapies, Combined Modality,Treatment, Multimodal,Treatments, Multimodal
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000971 Antineoplastic Combined Chemotherapy Protocols The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form. Anticancer Drug Combinations,Antineoplastic Agents, Combined,Antineoplastic Chemotherapy Protocols,Antineoplastic Drug Combinations,Cancer Chemotherapy Protocols,Chemotherapy Protocols, Antineoplastic,Drug Combinations, Antineoplastic,Antineoplastic Combined Chemotherapy Regimens,Combined Antineoplastic Agents,Agent, Combined Antineoplastic,Agents, Combined Antineoplastic,Anticancer Drug Combination,Antineoplastic Agent, Combined,Antineoplastic Chemotherapy Protocol,Antineoplastic Drug Combination,Cancer Chemotherapy Protocol,Chemotherapy Protocol, Antineoplastic,Chemotherapy Protocol, Cancer,Chemotherapy Protocols, Cancer,Combinations, Antineoplastic Drug,Combined Antineoplastic Agent,Drug Combination, Anticancer,Drug Combination, Antineoplastic,Drug Combinations, Anticancer,Protocol, Antineoplastic Chemotherapy,Protocol, Cancer Chemotherapy,Protocols, Antineoplastic Chemotherapy,Protocols, Cancer Chemotherapy
D013724 Teratoma A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642) Dysembryoma,Teratoid Tumor,Teratoma, Cystic,Teratoma, Mature,Teratoma, Benign,Teratoma, Immature,Teratoma, Malignant,Benign Teratoma,Benign Teratomas,Dysembryomas,Immature Teratoma,Immature Teratomas,Malignant Teratoma,Malignant Teratomas,Teratoid Tumors,Teratomas,Teratomas, Benign,Teratomas, Immature,Teratomas, Malignant,Tumor, Teratoid,Tumors, Teratoid
D013736 Testicular Neoplasms Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms. Cancer of Testis,Cancer of the Testes,Testicular Cancer,Testicular Neoplasm,Testicular Tumor,Testis Cancer,Cancer of the Testis,Neoplasms, Testicular,Neoplasms, Testis,Testicular Tumors,Testis Neoplasms,Tumor of Rete Testis,Cancer, Testicular,Cancer, Testis,Cancers, Testicular,Cancers, Testis,Neoplasm, Testicular,Neoplasm, Testis,Rete Testis Tumor,Rete Testis Tumors,Testicular Cancers,Testis Cancers,Testis Neoplasm,Testis Tumor, Rete,Testis Tumors, Rete,Tumor, Testicular,Tumors, Testicular

Related Publications

R L Jansen, and R Sylvester, and D T Sleyfer, and W W ten Bokkel Huinink, and S B Kaye, and W G Jones, and J Keizer, and A T van Oosterom, and S Meyer, and C P Vendrik
[Postchemotherapy surgery in patients with non-seminomatous testicular tumors].
November 1993, Bratislavske lekarske listy,
R L Jansen, and R Sylvester, and D T Sleyfer, and W W ten Bokkel Huinink, and S B Kaye, and W G Jones, and J Keizer, and A T van Oosterom, and S Meyer, and C P Vendrik
High-dose versus low-dose vinblastine in cisplatin-vinblastine-bleomycin combination chemotherapy of non-seminomatous testicular cancer: a randomized study of the EORTC Genitourinary Tract Cancer Cooperative Group.
August 1986, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
R L Jansen, and R Sylvester, and D T Sleyfer, and W W ten Bokkel Huinink, and S B Kaye, and W G Jones, and J Keizer, and A T van Oosterom, and S Meyer, and C P Vendrik
Compliance with follow-up of patients treated for non-seminomatous testicular cancer.
September 1991, British journal of cancer,
R L Jansen, and R Sylvester, and D T Sleyfer, and W W ten Bokkel Huinink, and S B Kaye, and W G Jones, and J Keizer, and A T van Oosterom, and S Meyer, and C P Vendrik
Metastatic Mature Teratoma and Growing Teratoma Syndrome in Patients with Testicular Non-Seminomatous Germ Cell Tumors.
October 2021, Korean journal of radiology,
R L Jansen, and R Sylvester, and D T Sleyfer, and W W ten Bokkel Huinink, and S B Kaye, and W G Jones, and J Keizer, and A T van Oosterom, and S Meyer, and C P Vendrik
The chemotherapy of disseminated testicular non-seminomatous germ cell tumors and the clinical research of the EORTC Genitourinary Group.
January 1985, Progress in clinical and biological research,
R L Jansen, and R Sylvester, and D T Sleyfer, and W W ten Bokkel Huinink, and S B Kaye, and W G Jones, and J Keizer, and A T van Oosterom, and S Meyer, and C P Vendrik
The chemotherapy of disseminated testicular non-seminomatous germ cell tumors and the clinical research of the EORTC Genitourinary Group.
January 1985, Acta urologica Belgica,
R L Jansen, and R Sylvester, and D T Sleyfer, and W W ten Bokkel Huinink, and S B Kaye, and W G Jones, and J Keizer, and A T van Oosterom, and S Meyer, and C P Vendrik
Testicular cancer patients: considerations in long-term follow-up.
April 2008, Hematology/oncology clinics of North America,
R L Jansen, and R Sylvester, and D T Sleyfer, and W W ten Bokkel Huinink, and S B Kaye, and W G Jones, and J Keizer, and A T van Oosterom, and S Meyer, and C P Vendrik
Long-term follow-up of an EORTC randomized prospective trial comparing intravesical bacille Calmette-Guérin-RIVM and mitomycin C in superficial bladder cancer. EORTC GU Group and the Dutch South East Cooperative Urological Group. European Organisation for Research and Treatment of Cancer Genito-Urinary Tract Cancer Collaborative Group.
September 1998, Urology,
R L Jansen, and R Sylvester, and D T Sleyfer, and W W ten Bokkel Huinink, and S B Kaye, and W G Jones, and J Keizer, and A T van Oosterom, and S Meyer, and C P Vendrik
5-Aza-2'-deoxycytidine (NSC 127716) in non-seminomatous testicular cancer. Phase II from the EORTC Early Clinical Trials Cooperative Group and Genito-Urinary Group.
May 1992, Annals of oncology : official journal of the European Society for Medical Oncology,
R L Jansen, and R Sylvester, and D T Sleyfer, and W W ten Bokkel Huinink, and S B Kaye, and W G Jones, and J Keizer, and A T van Oosterom, and S Meyer, and C P Vendrik
Long-term follow-up of residual masses after chemotherapy in patients with non-seminomatous germ cell tumours.
November 2000, British journal of cancer,
Copied contents to your clipboard!