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OBJECTIVE Lipopolysaccharide (LPS) is one of the major substances initiating the immune host response in microbial infections that results in cytotoxicity. In terms of treatment of the immune response, research has been conducted on physical environments that can reduce LPS-induced damage. In this experiment, a long-term continuous static magnetic field (SMF) was used as a physical resource to reduce LPS-induced immune host response. METHODS Cultured fibroblasts were challenged with LPS to initiate an inflammatory reaction. Cell viability and various proinflammatory cytokine levels were detected and compared between SMF and sham-exposed groups. RESULTS Our in vitro study revealed that, with LPS challenge, fibroblasts continuously exposed to a 0.4-T SMF for 12 h demonstrated higher cell viability compared to unexposed analogs. From cytokine test, the levels of LPS-induced interleukin-1beta (IL-1beta) in the SMF-exposed groups were significantly lower relative to their unexposed counterparts (p < 0.05). By contrast, SMF exposure tended to increase the level of LPS-induced IL-1 receptor antagonist (IL-1Ra) and IL-6. CONCLUSIONS Our results suggest that SMF stimulation inhibits LPS-induced cytotoxicity through reduction of proinflammatory cytokines and increase in anti-inflammatory cytokines of NIH-3T3 cells.
Che-Tong Lin, and
Sheng-Yang Lee, and
Chun-Yang Chen, and
Chi-An Chen, and
Chih-Ping Lin, and
Haw-Ming Huang
March 1999,
Magnetic resonance in medicine,
Che-Tong Lin, and
Sheng-Yang Lee, and
Chun-Yang Chen, and
Chi-An Chen, and
Chih-Ping Lin, and
Haw-Ming Huang
October 2022,
Biology,
Che-Tong Lin, and
Sheng-Yang Lee, and
Chun-Yang Chen, and
Chi-An Chen, and
Chih-Ping Lin, and
Haw-Ming Huang
January 2008,
American journal of physiology. Heart and circulatory physiology,
Che-Tong Lin, and
Sheng-Yang Lee, and
Chun-Yang Chen, and
Chi-An Chen, and
Chih-Ping Lin, and
Haw-Ming Huang
October 2004,
Bioelectromagnetics,
Che-Tong Lin, and
Sheng-Yang Lee, and
Chun-Yang Chen, and
Chi-An Chen, and
Chih-Ping Lin, and
Haw-Ming Huang
January 1983,
Kosmicheskaia biologiia i aviakosmicheskaia meditsina,
Che-Tong Lin, and
Sheng-Yang Lee, and
Chun-Yang Chen, and
Chi-An Chen, and
Chih-Ping Lin, and
Haw-Ming Huang
October 2011,
American journal of obstetrics and gynecology,
Che-Tong Lin, and
Sheng-Yang Lee, and
Chun-Yang Chen, and
Chi-An Chen, and
Chih-Ping Lin, and
Haw-Ming Huang
September 2003,
Bioelectromagnetics,
Che-Tong Lin, and
Sheng-Yang Lee, and
Chun-Yang Chen, and
Chi-An Chen, and
Chih-Ping Lin, and
Haw-Ming Huang
January 2011,
International journal of radiation biology,
Che-Tong Lin, and
Sheng-Yang Lee, and
Chun-Yang Chen, and
Chi-An Chen, and
Chih-Ping Lin, and
Haw-Ming Huang
January 1996,
Surgical neurology,
Che-Tong Lin, and
Sheng-Yang Lee, and
Chun-Yang Chen, and
Chi-An Chen, and
Chih-Ping Lin, and
Haw-Ming Huang
October 1994,
Hawaii medical journal,
