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Partially purified vascular permeability (VP) factor (VPF) of Bacillus cereus induced fluid accumulation in the ligated intestinal loops of mouse (MIL) and rabbit (RIL), suggesting that the VP activity may correlate with fluid accumulation in ligated intestinal loops of these animals. Fluid accumulation was observed at 6-8 hr in 55-67% of mouse intestinal loops inoculated with 40-50 immunodiffusion units (IDU) of partially purified VPF, whereas it was found at 2 hr in all loops with 400-600 IDU of partially purified VPF. In rabbit intestinal loops with 120-190 IDU of partially purified VPF, fluid accumulation was observed at 6 hr. From these findings, VPF produced by B. cereus can be easily detected in both MIL and RIL. The intestinal tissue of mouse intestinal loops was histopathologically damaged at different concentrations of the VPF to induce fluid accumulation. With 50 IDU of partially purified VPF, severe edema was found in the laminia proprial layer and submucosa. With 600 IDU of partially purified VPF, on the other hand, severe necrosis in the surface epithelium of villus and laminia proprial layer, and hyperemia in the submucosa were observed, suggesting that partially purified VPF may be cytotoxic and/or intestinecrotic.
K Shinagawa, and
K Sato, and
H Konuma, and
N Matsusaka, and
S Sugii
February 1979,
Applied and environmental microbiology,
K Shinagawa, and
K Sato, and
H Konuma, and
N Matsusaka, and
S Sugii
April 1991,
The Journal of veterinary medical science,
K Shinagawa, and
K Sato, and
H Konuma, and
N Matsusaka, and
S Sugii
April 1991,
The Journal of veterinary medical science,
K Shinagawa, and
K Sato, and
H Konuma, and
N Matsusaka, and
S Sugii
July 1979,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie,
K Shinagawa, and
K Sato, and
H Konuma, and
N Matsusaka, and
S Sugii
January 1983,
The Journal of antibiotics,
K Shinagawa, and
K Sato, and
H Konuma, and
N Matsusaka, and
S Sugii
September 1972,
Applied microbiology,
K Shinagawa, and
K Sato, and
H Konuma, and
N Matsusaka, and
S Sugii
January 1949,
Journal of bacteriology,
K Shinagawa, and
K Sato, and
H Konuma, and
N Matsusaka, and
S Sugii
January 1949,
Journal of bacteriology,
K Shinagawa, and
K Sato, and
H Konuma, and
N Matsusaka, and
S Sugii
January 1973,
Vestnik Akademii meditsinskikh nauk SSSR,
K Shinagawa, and
K Sato, and
H Konuma, and
N Matsusaka, and
S Sugii
January 1995,
Cancer research,
