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The aim of this study was to develop a model for pancreatic transplantation in the primate in order to test a new immunosuppressive drug. Initially, streptozotocin was used to induce insulin-dependent diabetes mellitus, but it was found to be ineffective and associated with a high morbidity. Furthermore, streptozotocin-induced insulin-dependent diabetes mellitus did not always persist, thus invalidating the evaluation of pancreatic graft function. Therefore, total pancreatectomy was introduced and combined with the pancreatic allotransplantation as a single procedure. Enteric diversion of the pancreatic juice was chosen since this avoids exocrine pancreatic insufficiency and facilitates the oral administration of the test drug. Intra-arterial monitoring of blood pressure and blood gases during the operation and avoidance of hypothermia in the animal were found to be the most important factors contributing to a successful outcome from the operative procedure.
B G Ericzon, and
R M Wijnen, and
K Kubota, and
A vd Bogaard, and
G Kootstra
November 2012,
Journal of hepato-biliary-pancreatic sciences,
B G Ericzon, and
R M Wijnen, and
K Kubota, and
A vd Bogaard, and
G Kootstra
March 2020,
Animal models and experimental medicine,
B G Ericzon, and
R M Wijnen, and
K Kubota, and
A vd Bogaard, and
G Kootstra
January 1981,
Journal of medical primatology,
B G Ericzon, and
R M Wijnen, and
K Kubota, and
A vd Bogaard, and
G Kootstra
December 2019,
Cellular reprogramming,
B G Ericzon, and
R M Wijnen, and
K Kubota, and
A vd Bogaard, and
G Kootstra
August 1999,
Transplantation,
B G Ericzon, and
R M Wijnen, and
K Kubota, and
A vd Bogaard, and
G Kootstra
September 1986,
Investigative ophthalmology & visual science,
B G Ericzon, and
R M Wijnen, and
K Kubota, and
A vd Bogaard, and
G Kootstra
January 1994,
Transplantation,
B G Ericzon, and
R M Wijnen, and
K Kubota, and
A vd Bogaard, and
G Kootstra
September 1990,
Teratology,
B G Ericzon, and
R M Wijnen, and
K Kubota, and
A vd Bogaard, and
G Kootstra
January 1985,
Annals of surgery,
B G Ericzon, and
R M Wijnen, and
K Kubota, and
A vd Bogaard, and
G Kootstra
August 1994,
Toxicology in vitro : an international journal published in association with BIBRA,
