An effective setting method (that is, a method using the variances of strain tensor component measurements) is described for the properly spatially varied regularization parameters for our shear modulus reconstruction. At each position, the respective strain variances can be experimentally evaluated using plural field measurements or single field measurement, for example, when using all crosscorrelation- based methods, by using the Ziv-Zakai Lower Bound (ZZLB). The demonstrated regularization by the single field measurement using the cross-spectrum phase gradient method (MCSPGM) in experiments confirms that the use of the axial strain variance estimated by the echo signal-to-noise ratio and correlations (the combined SNRc) effectively stabilizes the 1-D reconstruction on an agar phantom and a human in vivo liver carcinoma during interstitial microwave thermal treatment. The regularization yields a spatially uniform stability in reconstruction.