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ent-Kaurane Diterpenoids from Isodon nervosus. 2008
Li-Mei Li, and
Guo-You Li, and
Li-Sheng Ding, and
Li-Bin Yang, and
Yong Zhao, and
Jian-Xin Pu, and
Wei-Lie Xiao, and
Quan-Bin Han, and
Han-Dong Sun
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
A pentacyclic ent-kauranoid, nervonin A ( 1), with an unprecedented cyclobutane moiety in the structure, and nine other new ent-kaurane diterpenoids, nervonins B-J ( 2- 10), along with 10 known ones ( 11- 20), were isolated from Isodon nervosus. Their structures were elucidated by detailed spectroscopic analysis. All diterpenoids were assayed for their cytotoxicity against K562, A549, and HepG2 human cell lines. Compounds 2, 11, 16, 17, and 20 showed significant cytotoxicity.
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