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The high-affinity receptor for IgE (Fc epsilon RI) on mast cells and basophils is a tetrameric complex, alpha beta gamma 2. Here we summarize the latest developments on the structure and function of this receptor. By genetic transfer, we have engineered a cell line secreting substantial amounts of a peptide containing exclusively the extracellular domain of the alpha-subunit. This domain by itself is sufficient to mediate high-affinity binding of IgE. Glycosylation and the presence of the other subunits are not necessary for the binding function. The gamma-subunit of Fc epsilon RI is part of other receptors such as Fc gamma RIII and the T cell receptor, and therefore is likely to play an important although still undefined functional role. A detailed knowledge of how the receptor interacts with IgE and induces cellular degranulation may lead to the design of new therapeutic approaches to allergic diseases. The potential strategies are discussed.
J P Kinet, and
U Blank, and
A Brini, and
M H Jouvin, and
H Küster, and
O Mejan, and
C Ra
May 2016,
European journal of pharmacology,
J P Kinet, and
U Blank, and
A Brini, and
M H Jouvin, and
H Küster, and
O Mejan, and
C Ra
January 1994,
Chemical immunology,
J P Kinet, and
U Blank, and
A Brini, and
M H Jouvin, and
H Küster, and
O Mejan, and
C Ra
July 1998,
International archives of allergy and immunology,
J P Kinet, and
U Blank, and
A Brini, and
M H Jouvin, and
H Küster, and
O Mejan, and
C Ra
January 1986,
Annual review of immunology,
J P Kinet, and
U Blank, and
A Brini, and
M H Jouvin, and
H Küster, and
O Mejan, and
C Ra
January 1989,
Sub-cellular biochemistry,
J P Kinet, and
U Blank, and
A Brini, and
M H Jouvin, and
H Küster, and
O Mejan, and
C Ra
October 2007,
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
J P Kinet, and
U Blank, and
A Brini, and
M H Jouvin, and
H Küster, and
O Mejan, and
C Ra
September 1988,
JAMA,
J P Kinet, and
U Blank, and
A Brini, and
M H Jouvin, and
H Küster, and
O Mejan, and
C Ra
February 1994,
ImmunoMethods,
J P Kinet, and
U Blank, and
A Brini, and
M H Jouvin, and
H Küster, and
O Mejan, and
C Ra
April 2002,
Biochemical and biophysical research communications,
J P Kinet, and
U Blank, and
A Brini, and
M H Jouvin, and
H Küster, and
O Mejan, and
C Ra
February 1996,
Nihon rinsho. Japanese journal of clinical medicine,
