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The purpose of this meta-analysis was to estimate the effects of heparin flush and saline flush solutions on maintaining patency, preventing phlebitis, and increasing duration in peripheral heparin locks. The average effect size (d value) across 15 studies with a total sample size of 3,490 was .0573 for patency (clotting). The 95% credibility interval ranged from -.2267 to .3413. The average effect size across 13 studies with a total sample size of 2,356 was -.0757 for phlebitis. The 95% credibility interval ranged from -.2497 to .0983. The average effect size for duration across six samples with a total sample size of 1,960 was -.0550. The 95% credibility interval ranged from -.2424 to .1324. It can be concluded that saline is as effective as heparin in maintaining patency, preventing phlebitis, and increasing duration in peripheral intravenous locks. Quality of care can be enhanced by using saline as the flush solution, thereby eliminating problems associated with anticoagulant effects and drug incompatibilities. In addition, an estimated yearly savings of $109,100,000 to $218,200,000 U.S. health care dollars could be attained.
C J Goode, and
M Titler, and
B Rakel, and
D S Ones, and
C Kleiber, and
S Small, and
P K Triolo
January 1988,
Journal of intravenous nursing : the official publication of the Intravenous Nurses Society,
C J Goode, and
M Titler, and
B Rakel, and
D S Ones, and
C Kleiber, and
S Small, and
P K Triolo
September 2019,
Journal of family medicine and primary care,
C J Goode, and
M Titler, and
B Rakel, and
D S Ones, and
C Kleiber, and
S Small, and
P K Triolo
January 1987,
NITA,
C J Goode, and
M Titler, and
B Rakel, and
D S Ones, and
C Kleiber, and
S Small, and
P K Triolo
January 1991,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
C J Goode, and
M Titler, and
B Rakel, and
D S Ones, and
C Kleiber, and
S Small, and
P K Triolo
January 1989,
Kentucky nurse,
C J Goode, and
M Titler, and
B Rakel, and
D S Ones, and
C Kleiber, and
S Small, and
P K Triolo
August 1993,
Journal of emergency nursing,
C J Goode, and
M Titler, and
B Rakel, and
D S Ones, and
C Kleiber, and
S Small, and
P K Triolo
January 1998,
Pediatric nursing,
C J Goode, and
M Titler, and
B Rakel, and
D S Ones, and
C Kleiber, and
S Small, and
P K Triolo
July 2005,
Emerging infectious diseases,
C J Goode, and
M Titler, and
B Rakel, and
D S Ones, and
C Kleiber, and
S Small, and
P K Triolo
January 1995,
Pediatric nursing,
C J Goode, and
M Titler, and
B Rakel, and
D S Ones, and
C Kleiber, and
S Small, and
P K Triolo
January 1983,
NITA,
