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Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations. 1991
G Cimino, and
D T Moir, and
O Canaani, and
K Williams, and
W M Crist, and
S Katzav, and
L Cannizzaro, and
B Lange, and
P C Nowell, and
C M Croce
Jefferson Cancer Institute, Jefferson Cancer Center, Philadelphia, Pennsylvania.
Chromosomal region 11q23 participates in a number of reciprocal translocations with specific regions of chromosomes 4, 9, 19, and others. These translocations are associated with acute lymphocytic leukemia and acute myelomonocytic, monocytic, and myelogenous leukemia. From a yeast artificial chromosome containing human DNA derived from 11q23 we cloned a DNA fragment which can be used as a probe to detect rearrangements in leukemic cells from the majority of patients with the t(4;11), t(9;11), and t(11;19) translocations. The breakpoints cluster in a small DNA region of less than 5.8 kilobases.
Related Publications
G Cimino, and
D T Moir, and
O Canaani, and
K Williams, and
W M Crist, and
S Katzav, and
L Cannizzaro, and
B Lange, and
P C Nowell, and
C M Croce
May 1992,
Cancer research,
G Cimino, and
D T Moir, and
O Canaani, and
K Williams, and
W M Crist, and
S Katzav, and
L Cannizzaro, and
B Lange, and
P C Nowell, and
C M Croce
June 1992,
Leukemia & lymphoma,
G Cimino, and
D T Moir, and
O Canaani, and
K Williams, and
W M Crist, and
S Katzav, and
L Cannizzaro, and
B Lange, and
P C Nowell, and
C M Croce
March 1992,
Genes, chromosomes & cancer,
G Cimino, and
D T Moir, and
O Canaani, and
K Williams, and
W M Crist, and
S Katzav, and
L Cannizzaro, and
B Lange, and
P C Nowell, and
C M Croce
February 1996,
Blood,
G Cimino, and
D T Moir, and
O Canaani, and
K Williams, and
W M Crist, and
S Katzav, and
L Cannizzaro, and
B Lange, and
P C Nowell, and
C M Croce
November 1992,
Blood,
G Cimino, and
D T Moir, and
O Canaani, and
K Williams, and
W M Crist, and
S Katzav, and
L Cannizzaro, and
B Lange, and
P C Nowell, and
C M Croce
December 1991,
Leukemia,
G Cimino, and
D T Moir, and
O Canaani, and
K Williams, and
W M Crist, and
S Katzav, and
L Cannizzaro, and
B Lange, and
P C Nowell, and
C M Croce
October 1992,
Genes, chromosomes & cancer,
G Cimino, and
D T Moir, and
O Canaani, and
K Williams, and
W M Crist, and
S Katzav, and
L Cannizzaro, and
B Lange, and
P C Nowell, and
C M Croce
February 1988,
Cancer genetics and cytogenetics,
G Cimino, and
D T Moir, and
O Canaani, and
K Williams, and
W M Crist, and
S Katzav, and
L Cannizzaro, and
B Lange, and
P C Nowell, and
C M Croce
July 1996,
Cancer genetics and cytogenetics,
G Cimino, and
D T Moir, and
O Canaani, and
K Williams, and
W M Crist, and
S Katzav, and
L Cannizzaro, and
B Lange, and
P C Nowell, and
C M Croce
September 2011,
Leukemia research,
