BIOMAT Database Logo BIOMAT Database Logo

[Expression of peroxisome proliferator-activated receptor gamma in glioma]. 2008

Ming-hua Wang, and Xue-yun Zhong, and Chen-li Lin, and You-ke Xie, and Jin-ping Jia, and Su-mei Li, and Can Mi
Department of Pathology, Chongqing Medical Oniversity, Chongqing 410016, China. wangmhhh@yahoo.cn

OBJECTIVE To investigate the expression and significance of peroxisome proliferators-activated receptor gamma (PPAR gamma) in human glioma. METHODS Immunohistochemical staining for PPAR gamma was performed using biopsy specimens of human glioma of various histological types. Expression of PPAR gamma and GFAP in glioma cell lines SWO-38, U251 and SHG-44 were analyzed using Western blotting and reverse transcription-polymerase chain reaction (RT-PCR). RESULTS Immunohistochemical study showed that PPAR gamma was expressed in glioma tissues with positive rate of 37.5%. Western blotting and RT-PCR showed that PPAR gamma was expressed in both glioma cell lines SWO-38 and U251, but not in SHG-44 cells. However, high expression of GFAP was detected in SHG-44 cells. CONCLUSIONS PPAR gamma is associated with carcinogens of glioma. Actived PPAR gamma by agonist may be a novel approach to the treatment of glioma.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D001932 Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain. Brain Cancer,Brain Metastases,Brain Tumors,Cancer of Brain,Malignant Primary Brain Tumors,Neoplasms, Intracranial,Benign Neoplasms, Brain,Brain Neoplasm, Primary,Brain Neoplasms, Benign,Brain Neoplasms, Malignant,Brain Neoplasms, Malignant, Primary,Brain Neoplasms, Primary Malignant,Brain Tumor, Primary,Brain Tumor, Recurrent,Cancer of the Brain,Intracranial Neoplasms,Malignant Neoplasms, Brain,Malignant Primary Brain Neoplasms,Neoplasms, Brain,Neoplasms, Brain, Benign,Neoplasms, Brain, Malignant,Neoplasms, Brain, Primary,Primary Brain Neoplasms,Primary Malignant Brain Neoplasms,Primary Malignant Brain Tumors,Benign Brain Neoplasm,Benign Brain Neoplasms,Benign Neoplasm, Brain,Brain Benign Neoplasm,Brain Benign Neoplasms,Brain Cancers,Brain Malignant Neoplasm,Brain Malignant Neoplasms,Brain Metastase,Brain Neoplasm,Brain Neoplasm, Benign,Brain Neoplasm, Malignant,Brain Neoplasms, Primary,Brain Tumor,Brain Tumors, Recurrent,Cancer, Brain,Intracranial Neoplasm,Malignant Brain Neoplasm,Malignant Brain Neoplasms,Malignant Neoplasm, Brain,Neoplasm, Brain,Neoplasm, Intracranial,Primary Brain Neoplasm,Primary Brain Tumor,Primary Brain Tumors,Recurrent Brain Tumor,Recurrent Brain Tumors,Tumor, Brain
D005904 Glial Fibrillary Acidic Protein An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000. Glial Intermediate Filament Protein,Astroprotein,GFA-Protein,Glial Fibrillary Acid Protein,GFA Protein
D005910 Glioma Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21) Glial Cell Tumors,Malignant Glioma,Mixed Glioma,Glial Cell Tumor,Glioma, Malignant,Glioma, Mixed,Gliomas,Gliomas, Malignant,Gliomas, Mixed,Malignant Gliomas,Mixed Gliomas,Tumor, Glial Cell,Tumors, Glial Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012333 RNA, Messenger RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm. Messenger RNA,Messenger RNA, Polyadenylated,Poly(A) Tail,Poly(A)+ RNA,Poly(A)+ mRNA,RNA, Messenger, Polyadenylated,RNA, Polyadenylated,mRNA,mRNA, Non-Polyadenylated,mRNA, Polyadenylated,Non-Polyadenylated mRNA,Poly(A) RNA,Polyadenylated mRNA,Non Polyadenylated mRNA,Polyadenylated Messenger RNA,Polyadenylated RNA,RNA, Polyadenylated Messenger,mRNA, Non Polyadenylated
D015153 Blotting, Western Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes. Immunoblotting, Western,Western Blotting,Western Immunoblotting,Blot, Western,Immunoblot, Western,Western Blot,Western Immunoblot,Blots, Western,Blottings, Western,Immunoblots, Western,Immunoblottings, Western,Western Blots,Western Blottings,Western Immunoblots,Western Immunoblottings
D045744 Cell Line, Tumor A cell line derived from cultured tumor cells. Tumor Cell Line,Cell Lines, Tumor,Line, Tumor Cell,Lines, Tumor Cell,Tumor Cell Lines
D047495 PPAR gamma A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR ALPHA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES. It is a target of THIAZOLIDINEDIONES for control of DIABETES MELLITUS. PPARgamma,PPARgamma2,PPARgamma3,Peroxisome Proliferator-Activated Receptor gamma,Thiazolidinedione Receptor,mPPARgamma1,mPPARgamma2,Peroxisome Proliferator Activated Receptor gamma,Receptor, Thiazolidinedione
D020133 Reverse Transcriptase Polymerase Chain Reaction A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols. Polymerase Chain Reaction, Reverse Transcriptase,Reverse Transcriptase PCR,PCR, Reverse Transcriptase,Transcriptase PCR, Reverse

Related Publications

Ming-hua Wang, and Xue-yun Zhong, and Chen-li Lin, and You-ke Xie, and Jin-ping Jia, and Su-mei Li, and Can Mi
Peroxisome proliferator-activated receptor-gamma expression in lung.
July 2002, Chest,
Ming-hua Wang, and Xue-yun Zhong, and Chen-li Lin, and You-ke Xie, and Jin-ping Jia, and Su-mei Li, and Can Mi
[Peroxisome proliferator-activated receptor gamma (PPAR gamma)].
February 2001, Nihon rinsho. Japanese journal of clinical medicine,
Ming-hua Wang, and Xue-yun Zhong, and Chen-li Lin, and You-ke Xie, and Jin-ping Jia, and Su-mei Li, and Can Mi
Expression of Peroxisome Proliferator Activated Receptor gamma in Prostatic Adenocarcinoma.
May 2015, Journal of Korean medical science,
Ming-hua Wang, and Xue-yun Zhong, and Chen-li Lin, and You-ke Xie, and Jin-ping Jia, and Su-mei Li, and Can Mi
Repression of IFN-gamma expression by peroxisome proliferator-activated receptor gamma.
June 2004, Journal of immunology (Baltimore, Md. : 1950),
Ming-hua Wang, and Xue-yun Zhong, and Chen-li Lin, and You-ke Xie, and Jin-ping Jia, and Su-mei Li, and Can Mi
Peroxisome proliferator-activated receptor gamma in osteoarthritis.
February 2011, Modern rheumatology,
Ming-hua Wang, and Xue-yun Zhong, and Chen-li Lin, and You-ke Xie, and Jin-ping Jia, and Su-mei Li, and Can Mi
Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis.
May 2003, Gastroenterology,
Ming-hua Wang, and Xue-yun Zhong, and Chen-li Lin, and You-ke Xie, and Jin-ping Jia, and Su-mei Li, and Can Mi
Decreased expression of peroxisome proliferator activated receptor gamma in cftr-/- mice.
August 2004, Journal of cellular physiology,
Ming-hua Wang, and Xue-yun Zhong, and Chen-li Lin, and You-ke Xie, and Jin-ping Jia, and Su-mei Li, and Can Mi
Peroxisome proliferator-activated receptor gamma and BRCA1.
February 2019, Endocrine-related cancer,
Ming-hua Wang, and Xue-yun Zhong, and Chen-li Lin, and You-ke Xie, and Jin-ping Jia, and Su-mei Li, and Can Mi
Peroxisome proliferator-activated receptor gamma and cancers.
January 2003, Clinical cancer research : an official journal of the American Association for Cancer Research,
Ming-hua Wang, and Xue-yun Zhong, and Chen-li Lin, and You-ke Xie, and Jin-ping Jia, and Su-mei Li, and Can Mi
Peroxisome proliferator-activated receptor gamma and atherosclerosis.
February 2002, Current hypertension reports,
Copied contents to your clipboard!