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We studied the effects of OKY-046 (1, 10, and 30 mg/kg iv), a selective thromboxane synthase inhibitor, and of ICI 192605 (0.5 mg/kg), a selective thromboxane A2 receptor antagonist, on airflow obstruction and airway microvascular leakage induced by inhaled platelet-activating factor (PAF). Extravasated Evans blue dye content was measured as a reflection of airway microvascular leakage. In control animals, PAF caused a significantly higher increase in extravasation of dye and significantly less increase in lung resistance (RL) than histamine. OKY-046 significantly inhibited both changes in RL and airway microvascular leakage after PAF in a dose-dependent manner, whereas it inhibited histamine-induced airway microvascular leakage only at main bronchi, without any significant effect on RL. ICI 192605 significantly inhibited both RL and airway microvascular leakage induced by PAF, but not after histamine. After both PAF and histamine, changes in RL correlated significantly with the degree of microvascular leakage. Airway microvascular leakage and airflow obstruction after PAF, but not after histamine, may be dependent on thromboxane A2 generation.
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J O Lötvall, and
A Morikawa, and
P J Barnes, and
K F Chung
March 1986,
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K Tokuyama, and
J O Lötvall, and
A Morikawa, and
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K F Chung
March 1993,
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K Tokuyama, and
J O Lötvall, and
A Morikawa, and
P J Barnes, and
K F Chung
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K Tokuyama, and
J O Lötvall, and
A Morikawa, and
P J Barnes, and
K F Chung
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The Journal of pharmacy and pharmacology,
K Tokuyama, and
J O Lötvall, and
A Morikawa, and
P J Barnes, and
K F Chung
October 1993,
Arerugi = [Allergy],
K Tokuyama, and
J O Lötvall, and
A Morikawa, and
P J Barnes, and
K F Chung
March 1995,
European journal of pharmacology,
K Tokuyama, and
J O Lötvall, and
A Morikawa, and
P J Barnes, and
K F Chung
January 1995,
Journal of lipid mediators and cell signalling,
K Tokuyama, and
J O Lötvall, and
A Morikawa, and
P J Barnes, and
K F Chung
January 1991,
Arerugi = [Allergy],
K Tokuyama, and
J O Lötvall, and
A Morikawa, and
P J Barnes, and
K F Chung
January 2002,
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K Tokuyama, and
J O Lötvall, and
A Morikawa, and
P J Barnes, and
K F Chung
January 1989,
The American journal of physiology,
