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A short-term trial of isradipine was conducted in order to assess its effectiveness and tolerability in the treatment of mild to moderate HT. The study took place in general practice on 2702 patients, aged 18 to 70, with diastolic BP (dBP) from 95 to 114 mmHg. It included a pretreatment phase of up to four weeks out of antihypertensive drugs and on placebo and a twelve week treatment phase on isradipine 2.5 mg or 5.0 mg/day. After treatment with isradipine sBP fell from 168.0 to 148.1 and dBP from 102.7 to 86.7 mmHg. The majority of patients (89.6%) had a fall in dBP over 10 mmHg; 86.2% had normal dBP (= less than 90 mmHg) in the end. Adverse effects were referred by 2.8% of the patients. Satisfaction with the drug reached 90% among patients and physicians. Thus, isradipine proved effective and very well tolerated and may deserve a place as first line treatment for hypertension.
J M Miguel, and
A C Nunes, and
F R Gonçalves, and
G M Pêgo
October 1991,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
J M Miguel, and
A C Nunes, and
F R Gonçalves, and
G M Pêgo
January 1998,
Clinical therapeutics,
J M Miguel, and
A C Nunes, and
F R Gonçalves, and
G M Pêgo
March 1993,
American journal of hypertension,
J M Miguel, and
A C Nunes, and
F R Gonçalves, and
G M Pêgo
October 1986,
Cardiologia (Rome, Italy),
J M Miguel, and
A C Nunes, and
F R Gonçalves, and
G M Pêgo
June 1980,
AMB : revista da Associacao Medica Brasileira,
J M Miguel, and
A C Nunes, and
F R Gonçalves, and
G M Pêgo
January 1992,
Journal of cardiovascular pharmacology,
J M Miguel, and
A C Nunes, and
F R Gonçalves, and
G M Pêgo
October 1988,
Minerva cardioangiologica,
J M Miguel, and
A C Nunes, and
F R Gonçalves, and
G M Pêgo
January 1992,
Journal of cardiovascular pharmacology,
J M Miguel, and
A C Nunes, and
F R Gonçalves, and
G M Pêgo
June 1995,
The Journal of the Association of Physicians of India,
J M Miguel, and
A C Nunes, and
F R Gonçalves, and
G M Pêgo
January 1992,
Arquivos brasileiros de cardiologia,
