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We have enhanced the uptake of 5-[125I]iodo-2'-deoxyuridine (125IUdR) in Chinese hamster V79 cells with 5-fluoro-2'-deoxyuridine (FUdR) and have examined the combined toxicity of these agents. Although the uptake of 125IUdR increases approximately 3.2 +/- 0.5-fold in the presence of 1 microM FUdR, when cell survival fraction is plotted as a function of intranuclear 125IUdR content, the biphasic curve obtained reaches a plateau at a higher survival fraction than with control cells not exposed to FUdR. The results suggest that a greater number of cells were prevented from entering the S phase and consequently from incorporating 125IUdR. An FUdR- 125IUdR combination, therefore, does not seem to enhance the therapeutic potential of 125IUdR. Such observations are also of importance when FUdR and other inhibitors are used to enhance cold IUdR uptake in an effort to obtain an increase in radiosensitization effects.
A I Kassis, and
W E Guptill, and
R A Taube, and
S J Adelstein
June 1989,
Radiation research,
A I Kassis, and
W E Guptill, and
R A Taube, and
S J Adelstein
December 1987,
Cancer treatment reviews,
A I Kassis, and
W E Guptill, and
R A Taube, and
S J Adelstein
May 2001,
International journal of radiation biology,
A I Kassis, and
W E Guptill, and
R A Taube, and
S J Adelstein
January 1968,
Experimental cell research,
A I Kassis, and
W E Guptill, and
R A Taube, and
S J Adelstein
July 1962,
Cancer chemotherapy reports,
A I Kassis, and
W E Guptill, and
R A Taube, and
S J Adelstein
August 1987,
Radiation research,
A I Kassis, and
W E Guptill, and
R A Taube, and
S J Adelstein
February 1981,
British journal of experimental pathology,
A I Kassis, and
W E Guptill, and
R A Taube, and
S J Adelstein
December 1981,
Radiation research,
A I Kassis, and
W E Guptill, and
R A Taube, and
S J Adelstein
January 1990,
The Journal of nuclear medicine and allied sciences,
A I Kassis, and
W E Guptill, and
R A Taube, and
S J Adelstein
December 1962,
British medical journal,
