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Levels of interferon in adult bovine serum and in fetal bovine serum and tissues were examined during the course of transplacental bovine viral diarrhea virus infection. The cows produced circulating interferon between 2 and 9 days after viral inoculation, with mean peak levels in the serum on day 4. Interferon could be routinely detected in fetal tissues (e.g., thymus, spleen, and kidney) between days 4 and 21 after viral inoculation of the cows at 149 to 150 days of gestation (mid-second trimester) and in fetal serum from day 13 through day 21. Interferon was also detectable in the serum and tissues of fetuses from dams infected at day 95 of gestation (the beginning of the second trimester). In general, no differences were found between the ability of the adult and fetus to produce interferon. Fetal lamb kidney cells were more sensitive to the antiviral effects of bovine interferon than were fetal bovine kidney cells. The antiviral substance from the fetal and adult animals was characterized as interferon by standard criteria.
C R Rinaldo, and
D W Isackson, and
J C Overall, and
L A Glasgow, and
T T Brown, and
S I Bistner, and
J H Gillespie, and
F W Scott
April 2014,
Virus research,
C R Rinaldo, and
D W Isackson, and
J C Overall, and
L A Glasgow, and
T T Brown, and
S I Bistner, and
J H Gillespie, and
F W Scott
December 2020,
Veterinary immunology and immunopathology,
C R Rinaldo, and
D W Isackson, and
J C Overall, and
L A Glasgow, and
T T Brown, and
S I Bistner, and
J H Gillespie, and
F W Scott
June 1999,
Virology,
C R Rinaldo, and
D W Isackson, and
J C Overall, and
L A Glasgow, and
T T Brown, and
S I Bistner, and
J H Gillespie, and
F W Scott
November 2017,
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc,
C R Rinaldo, and
D W Isackson, and
J C Overall, and
L A Glasgow, and
T T Brown, and
S I Bistner, and
J H Gillespie, and
F W Scott
October 2010,
American journal of reproductive immunology (New York, N.Y. : 1989),
C R Rinaldo, and
D W Isackson, and
J C Overall, and
L A Glasgow, and
T T Brown, and
S I Bistner, and
J H Gillespie, and
F W Scott
June 2018,
Pathogens (Basel, Switzerland),
C R Rinaldo, and
D W Isackson, and
J C Overall, and
L A Glasgow, and
T T Brown, and
S I Bistner, and
J H Gillespie, and
F W Scott
October 1982,
Canadian journal of comparative medicine : Revue canadienne de medecine comparee,
C R Rinaldo, and
D W Isackson, and
J C Overall, and
L A Glasgow, and
T T Brown, and
S I Bistner, and
J H Gillespie, and
F W Scott
January 2000,
Revista Argentina de microbiologia,
C R Rinaldo, and
D W Isackson, and
J C Overall, and
L A Glasgow, and
T T Brown, and
S I Bistner, and
J H Gillespie, and
F W Scott
January 2009,
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research,
C R Rinaldo, and
D W Isackson, and
J C Overall, and
L A Glasgow, and
T T Brown, and
S I Bistner, and
J H Gillespie, and
F W Scott
December 1998,
The Journal of veterinary medical science,
