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9-(beta-TD-xylofuranosyl)guanine (xylo-G) was converted chemically to the 9-(beta-D-xylofuranosyl)guanine 5'-monophosphate (xylo-GMP) and 9-(beta-D-xylofuranosyl)guanine cyclic 3',5'-monophosphate (c-xylo-GMP). These compounds were tested against a variety of DNA viruses in tissue culture in parallel with 9-(beta-D-arabinofuranosyl)adenine (ara-A). This evaluation revealed that xylo-G, xylo-GMP, and c-xylo-GMP were all moderately active but less effective than ara-A. When the four compounds were administered intracerebrally as a treatment for herpes virus, type 1 induced encephalitis in mice, c-xylo-GMP exhibited superior activity to that shown by the other three. When administered intraperitoneally, c-xylo-GMP was found to have a therapeutic index of about 4, which is less than that for ara-A (approximately 30) in the same system.
G R Revankar, and
J H Huffman, and
R W Sidwell, and
R L Tolman, and
R K Robins, and
L B Allen
January 1973,
Chemotherapy,
G R Revankar, and
J H Huffman, and
R W Sidwell, and
R L Tolman, and
R K Robins, and
L B Allen
March 1974,
Journal of medicinal chemistry,
G R Revankar, and
J H Huffman, and
R W Sidwell, and
R L Tolman, and
R K Robins, and
L B Allen
March 1970,
Journal of pharmaceutical sciences,
G R Revankar, and
J H Huffman, and
R W Sidwell, and
R L Tolman, and
R K Robins, and
L B Allen
July 1984,
The Journal of biological chemistry,
G R Revankar, and
J H Huffman, and
R W Sidwell, and
R L Tolman, and
R K Robins, and
L B Allen
January 1967,
Journal of medicinal chemistry,
G R Revankar, and
J H Huffman, and
R W Sidwell, and
R L Tolman, and
R K Robins, and
L B Allen
November 1977,
The Journal of organic chemistry,
G R Revankar, and
J H Huffman, and
R W Sidwell, and
R L Tolman, and
R K Robins, and
L B Allen
January 2001,
Nucleosides, nucleotides & nucleic acids,
G R Revankar, and
J H Huffman, and
R W Sidwell, and
R L Tolman, and
R K Robins, and
L B Allen
December 1976,
Antimicrobial agents and chemotherapy,
G R Revankar, and
J H Huffman, and
R W Sidwell, and
R L Tolman, and
R K Robins, and
L B Allen
November 1980,
Cancer research,
G R Revankar, and
J H Huffman, and
R W Sidwell, and
R L Tolman, and
R K Robins, and
L B Allen
January 1984,
Archives of virology,
