-transparent.png){kind=logo}
Nondefective and transformation-defective virion subunit RNAs from two strains of Rous sarcoma virus (RSV) were translated in cell-free systems derived from Krebs IIA ascites cells, wheat germ, and L-cells. In each case the predominant viral-specific product was a polypeptide of molecular weight 76,000 that is related to the internal viral group-specific antigens, as judged by immunoprecipitation with monospecific antisera and tryptic peptide fingerprinting. No difference could be detected between the translation products of 35S RNA from nondefective and transformation-defective RSV virions, nor of 35S RNA from different strains of RSV. The 76,000-molecular-weight polypeptide synthesized in response to 35S RNA in vitro was labeled with formyl-methionine from initiator tRNA. Models for viral protein synthesis are discussed in the light of these results, and arguments positioning the group-specific antigen gene at the 5' end of the 35S RNA are presented.
T Pawson, and
G S Martin, and
A E Smith
October 1976,
Virology,
T Pawson, and
G S Martin, and
A E Smith
January 1980,
Intervirology,
T Pawson, and
G S Martin, and
A E Smith
November 1974,
Virology,
T Pawson, and
G S Martin, and
A E Smith
February 1975,
Proceedings of the National Academy of Sciences of the United States of America,
T Pawson, and
G S Martin, and
A E Smith
April 1973,
Nature: New biology,
T Pawson, and
G S Martin, and
A E Smith
December 1981,
Journal of virology,
T Pawson, and
G S Martin, and
A E Smith
April 1974,
Journal of virology,
T Pawson, and
G S Martin, and
A E Smith
February 1980,
Virology,
T Pawson, and
G S Martin, and
A E Smith
April 1975,
Proceedings of the National Academy of Sciences of the United States of America,
T Pawson, and
G S Martin, and
A E Smith
October 1990,
Nucleic acids research,
