Biomaterial Database

[Toxicologic investigations of selected phenolic compounds. I. Acute and subacute toxicity of guaiacol, methyl-guaiacol and syringol]. 1991

J Orłowski, and D Boruszak

Katedry i Zakładu Toksykologii, Akademii Medycznej im. K. Marcinkowskiego, Poznaniu. [

The aim of the investigations were determination of acute (A-DL50) and subacute (C-DL50) toxicity of guaiacol, methyl-guaiacol and syringol. White Wistar male rats, body weight 250 g +/- 20, were used. From the data obtained it was concluded that tested compounds could be classified to the fourth toxicity class (Hodge-Sterner classification). Cumulation coefficients show that no cumulation of there compounds occurs in a rat organism.

UI	MeSH Term	Description	Entries
D007928	Lethal Dose 50	The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.	LD50,Dose 50, Lethal
D008297	Male		Males
D011748	Pyrogallol	A trihydroxybenzene or dihydroxy phenol that can be prepared by heating GALLIC ACID.	1,2,3-Trihydroxybenzene,Pyrogallic acid,acid, Pyrogallic
D005260	Female		Females
D006139	Guaiacol	An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747)	2-Hydroxy-Anisole,2-Hydroxyanisole,2-Methoxy-Phenol,2-Methoxyphenol,Guaicol,Methyl Catechol,Catechol, Methyl
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D017208	Rats, Wistar	A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.	Wistar Rat,Rat, Wistar,Wistar Rats
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus