In this study, presents an innovative method for nanoparticle synthesis system for nanosized ZnO fabrication with powder or suspension type. The experimental device is primarily composed of a high frequency induction heating system, a pressure control system, a temperature control system and an automatic nanoparticle collection system. This study employs an automatic collection system with liquid nitrogen to condense and collect the nanoparticles. The influence of such process variables such as heating temperature and vacuum pressure are analyzed and compared through experimentation in order to identify the working conditions most conducive to the production of nanoparticles with smaller mean particle size. The prepared ZnO nanoparticles are characterized for nanostructural properties by the TEM and XRD. An Ultraviolet-Visible (UV-Vis) spectrophotometer is used to analyze the optical property of the nanoparticles. The ZnO nanofluid already has good dispersion, so even without dispersant, it can still remain in stable suspension for a fairly long time. Experimental results indicate that the particle size of produced ZnO nanoparticles is around 20 nm and with the production rate of 1.24 g/min.