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Synthesis, characterization and high in vitro antitumour activity of novel triphenyltin carboxylates. 1994
M Gielen, and
A El Khloufi, and
M Biesemans, and
A Bouhdid, and
D de Vos, and
B Mahieu, and
R Willem
Free University of Brussels (V.U.B.) Pleinlaan 2 Faculty of Applied Sciences Laboratory for General and Organic Chemistry (AOSC), Room 8G512 Brussels B-1050 Belgium.
The synthesis and spectral characterization of six novel triphenyltin compounds are described. The in vitro antitumour activity of three of these compounds against two human tumour cell lines, MCF-7, a mammary tumour, and WiDr, a colon carcinoma, was determined. All three compounds are more active than cis-platin, etoposide and doxorubicin against both tumour cell lines. They are as active as mitomycin C against WiDr, but less active against MCF-7.
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