-transparent.png){kind=logo}
Atrial natriuretic peptide (ANP), first isolated from rat atrial cardiocytes, is a potent natriuretic, diuretic and vasorelaxant hormone when given intravenously. In keeping with increasing evidence that many bioactive peptides that were first discovered in peripheral organs, are often present in the central nervous system, ANP and its binding sites have been localized on neurons in different regions of the brain. Further, ANP binding sites have been found on primary astrocyte and glial cell lines and ligand binding results in cyclic GMP production. In this review, we shall discuss the possible role of ANP as a neuromodulator and its effects on astrocytes, the most numerous cell type in mammalian brain.
V T Yeung, and
C K Lai, and
C S Cockram, and
R Teoh, and
J D Young, and
T G Yandle, and
M G Nicholls
December 1988,
Cellular and molecular neurobiology,
V T Yeung, and
C K Lai, and
C S Cockram, and
R Teoh, and
J D Young, and
T G Yandle, and
M G Nicholls
March 1990,
Archives internationales de physiologie et de biochimie,
V T Yeung, and
C K Lai, and
C S Cockram, and
R Teoh, and
J D Young, and
T G Yandle, and
M G Nicholls
February 1990,
The American journal of physiology,
V T Yeung, and
C K Lai, and
C S Cockram, and
R Teoh, and
J D Young, and
T G Yandle, and
M G Nicholls
October 1987,
Sheng li ke xue jin zhan [Progress in physiology],
V T Yeung, and
C K Lai, and
C S Cockram, and
R Teoh, and
J D Young, and
T G Yandle, and
M G Nicholls
June 1991,
Molecular and cellular neurosciences,
V T Yeung, and
C K Lai, and
C S Cockram, and
R Teoh, and
J D Young, and
T G Yandle, and
M G Nicholls
March 1987,
Endocrinology and metabolism clinics of North America,
V T Yeung, and
C K Lai, and
C S Cockram, and
R Teoh, and
J D Young, and
T G Yandle, and
M G Nicholls
June 1988,
Brain research bulletin,
V T Yeung, and
C K Lai, and
C S Cockram, and
R Teoh, and
J D Young, and
T G Yandle, and
M G Nicholls
January 1990,
Archives internationales de pharmacodynamie et de therapie,
V T Yeung, and
C K Lai, and
C S Cockram, and
R Teoh, and
J D Young, and
T G Yandle, and
M G Nicholls
February 1986,
Lancet (London, England),
V T Yeung, and
C K Lai, and
C S Cockram, and
R Teoh, and
J D Young, and
T G Yandle, and
M G Nicholls
June 1991,
Hypertension (Dallas, Tex. : 1979),
