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1. A bioassay cascade superfusion technique was utilized to study the properties of endothelium derived relaxing factor (EDRF) from human umbilical vein (HUV) and compare its actions on umbilical, chorionic plate and bovine pulmonary arterial strips. 2. Histamine (1 microM), bradykinin (1 microM) and A-23187 (0.3 microM, 1 microM) but not acetylcholine (1 microM) released EDRF. 3. The non-innervated human foetoplacental vessels, i.e., umbilical and chorionic plate arteries, do relax to EDRF by a guanosine 3':5'-cyclic monophosphate (cyclic GMP)-mediated mechanism. 4. The sensitivity of the human umbilical arterial strips to EDRF was less than that of the chronic plate arterial strips. Bovine pulmonary arterial strips were the most sensitive to the relaxant actions of human umbilical EDRF.
G Chaudhuri, and
G M Buga, and
M E Gold, and
K S Wood, and
L J Ignarro
April 1987,
Circulation research,
G Chaudhuri, and
G M Buga, and
M E Gold, and
K S Wood, and
L J Ignarro
September 1988,
Journal of the American College of Cardiology,
G Chaudhuri, and
G M Buga, and
M E Gold, and
K S Wood, and
L J Ignarro
January 1989,
Pharmacology & therapeutics,
G Chaudhuri, and
G M Buga, and
M E Gold, and
K S Wood, and
L J Ignarro
July 1992,
Fukuoka igaku zasshi = Hukuoka acta medica,
G Chaudhuri, and
G M Buga, and
M E Gold, and
K S Wood, and
L J Ignarro
August 1988,
Biochemical Society transactions,
G Chaudhuri, and
G M Buga, and
M E Gold, and
K S Wood, and
L J Ignarro
July 1997,
Canadian journal of physiology and pharmacology,
G Chaudhuri, and
G M Buga, and
M E Gold, and
K S Wood, and
L J Ignarro
February 1992,
Japanese circulation journal,
G Chaudhuri, and
G M Buga, and
M E Gold, and
K S Wood, and
L J Ignarro
January 1989,
Zeitschrift fur Kardiologie,
G Chaudhuri, and
G M Buga, and
M E Gold, and
K S Wood, and
L J Ignarro
June 1990,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
G Chaudhuri, and
G M Buga, and
M E Gold, and
K S Wood, and
L J Ignarro
December 1985,
Agents and actions,
