Effect of acute gouty arthritis on sleep patterns: a preclinical study. 2009

Uriah Guevara-López, and Fructuoso Ayala-Guerrero, and Alfredo Covarrubias-Gómez, and Francisco J López-Muñoz, and Ruben Torres-González
Department of Pain and Palliative Medicine, National Institute for Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico. uriahguevara@gmail.com

BACKGROUND It has been demonstrated that the interrelation between pain and sleep produces changes in sleep patterns and pain perception. Although some evidences suggest that sleep and pain may interact in a complex way, polysomnographic studies in animals with acute nociception are limited in number. OBJECTIVE This study was carried out in order to evaluate the effect of intra-articular knee injection of uric acid on sleep-wake patterns. METHODS Surgical electrode implantation was performed in seven anesthetized Wistar rats to carry out 10 h polysomnographic recordings. Acute nociception was induced by the intra-articular administration of 30% uric acid crystals into the knee joint of the right hind limb. Two recordings before and after intra-articular drug administration were obtained. Sleep-wake parameters were classified as (i) wakefulness (W), (ii) slow wave sleep (SWS), and (iii) rapid eye movement (REM) sleep. Frequency and duration from each parameter were evaluated under the two above-mentioned conditions. RESULTS Intra-articular administration of uric acid induced: (i) an increased duration of wakefulness (p=0.014), (ii) a decrement in the duration (p=0.001) and number of events (p=0.027) in REM sleep, and (iii) a decrement in the total sleep time (p=0.001). SWS did not present statistical differences between groups. CONCLUSIONS These data suggest that a nociceptive stimulus, induced by the intra-articular administration of uric acid, alters the sleep-wake equilibrium with REM sleep being particularly altered. However, further research concerning pain-sleep interaction is needed.

UI MeSH Term Description Entries
D007270 Injections, Intra-Articular Methods of delivering drugs into a joint space. Intra Articular Injection,Intraarticular Injection,Injections, Intraarticular,Intra-Articular Injections,Intraarticular Injections,Articular Injection, Intra,Articular Injections, Intra,Injection, Intra Articular,Injection, Intra-Articular,Injection, Intraarticular,Injections, Intra Articular,Intra Articular Injections,Intra-Articular Injection
D008297 Male Males
D010146 Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. Suffering, Physical,Ache,Pain, Burning,Pain, Crushing,Pain, Migratory,Pain, Radiating,Pain, Splitting,Aches,Burning Pain,Burning Pains,Crushing Pain,Crushing Pains,Migratory Pain,Migratory Pains,Pains, Burning,Pains, Crushing,Pains, Migratory,Pains, Radiating,Pains, Splitting,Physical Suffering,Physical Sufferings,Radiating Pain,Radiating Pains,Splitting Pain,Splitting Pains,Sufferings, Physical
D010147 Pain Measurement Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies. Analgesia Tests,Analogue Pain Scale,Formalin Test,McGill Pain Questionnaire,Nociception Tests,Pain Assessment,Pain Intensity,Pain Severity,Tourniquet Pain Test,Visual Analogue Pain Scale,Analog Pain Scale,Assessment, Pain,McGill Pain Scale,Visual Analog Pain Scale,Analgesia Test,Analog Pain Scales,Analogue Pain Scales,Formalin Tests,Intensity, Pain,Measurement, Pain,Nociception Test,Pain Assessments,Pain Intensities,Pain Measurements,Pain Questionnaire, McGill,Pain Scale, Analog,Pain Scale, Analogue,Pain Scale, McGill,Pain Severities,Pain Test, Tourniquet,Questionnaire, McGill Pain,Scale, Analog Pain,Scale, Analogue Pain,Scale, McGill Pain,Severity, Pain,Test, Analgesia,Test, Formalin,Test, Nociception,Test, Tourniquet Pain,Tests, Nociception,Tourniquet Pain Tests
D004567 Electrodes, Implanted Surgically placed electric conductors through which ELECTRIC STIMULATION is delivered to or electrical activity is recorded from a specific point inside the body. Implantable Electrodes,Implantable Stimulation Electrodes,Implanted Electrodes,Implanted Stimulation Electrodes,Electrode, Implantable,Electrode, Implantable Stimulation,Electrode, Implanted,Electrode, Implanted Stimulation,Electrodes, Implantable,Electrodes, Implantable Stimulation,Electrodes, Implanted Stimulation,Implantable Electrode,Implantable Stimulation Electrode,Implanted Electrode,Implanted Stimulation Electrode,Stimulation Electrode, Implantable,Stimulation Electrode, Implanted,Stimulation Electrodes, Implantable,Stimulation Electrodes, Implanted
D004569 Electroencephalography Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain. EEG,Electroencephalogram,Electroencephalograms
D006614 Hindlimb Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73) Hindlimbs
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001143 Arousal Cortical vigilance or readiness of tone, presumed to be in response to sensory stimulation via the reticular activating system. Vigilance, Cortical,Arousals,Cortical Vigilance
D001522 Behavior, Animal The observable response an animal makes to any situation. Autotomy Animal,Animal Behavior,Animal Behaviors

Related Publications

Uriah Guevara-López, and Fructuoso Ayala-Guerrero, and Alfredo Covarrubias-Gómez, and Francisco J López-Muñoz, and Ruben Torres-González
January 1994, Scandinavian journal of rheumatology,
Uriah Guevara-López, and Fructuoso Ayala-Guerrero, and Alfredo Covarrubias-Gómez, and Francisco J López-Muñoz, and Ruben Torres-González
January 1976, Arthritis and rheumatism,
Uriah Guevara-López, and Fructuoso Ayala-Guerrero, and Alfredo Covarrubias-Gómez, and Francisco J López-Muñoz, and Ruben Torres-González
August 1993, Postgraduate medicine,
Uriah Guevara-López, and Fructuoso Ayala-Guerrero, and Alfredo Covarrubias-Gómez, and Francisco J López-Muñoz, and Ruben Torres-González
January 1957, Archivos medicos de Cuba,
Uriah Guevara-López, and Fructuoso Ayala-Guerrero, and Alfredo Covarrubias-Gómez, and Francisco J López-Muñoz, and Ruben Torres-González
December 2007, Zhongguo zhen jiu = Chinese acupuncture & moxibustion,
Uriah Guevara-López, and Fructuoso Ayala-Guerrero, and Alfredo Covarrubias-Gómez, and Francisco J López-Muñoz, and Ruben Torres-González
January 2015, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology,
Uriah Guevara-López, and Fructuoso Ayala-Guerrero, and Alfredo Covarrubias-Gómez, and Francisco J López-Muñoz, and Ruben Torres-González
May 2009, Zhongguo zhen jiu = Chinese acupuncture & moxibustion,
Uriah Guevara-López, and Fructuoso Ayala-Guerrero, and Alfredo Covarrubias-Gómez, and Francisco J López-Muñoz, and Ruben Torres-González
January 2012, The American journal of Chinese medicine,
Uriah Guevara-López, and Fructuoso Ayala-Guerrero, and Alfredo Covarrubias-Gómez, and Francisco J López-Muñoz, and Ruben Torres-González
February 1958, Arthritis and rheumatism,
Uriah Guevara-López, and Fructuoso Ayala-Guerrero, and Alfredo Covarrubias-Gómez, and Francisco J López-Muñoz, and Ruben Torres-González
May 1982, JAMA,
Copied contents to your clipboard!