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The effects of dibutyryl cyclic AMP (DBcAMP) on ventricular vulnerability during complete atrioventricular block (CAVB) were studied one week after transarterial electrical ablation of the AV junction in 18 closed-chest dogs. All dogs exhibited CAVB and a stable ventricular escape rhythm with a mean cycle length of 1812 +/- 638 ms. After the administration of DBcAMP at a rate of 0.1 mg/kg/min for 30 min, the ventricular cycle length was significantly shortened, and the QTc interval was slightly prolonged, although the QT interval did not change. The ventricular fibrillation threshold after the administration of DBcAMP was significantly increased (from 12.2 +/- 3 84 to 18.4 +/- 5.08 mA, p less than 0.01). Thus, it was demonstrated that DBcAMP exhibited suppressive effects on the ventricular vulnerability in the experimentally induced CAVB.
K Kumagai, and
E Tashiro, and
N Tashiro, and
K Moroe, and
T Hiroki, and
K Arakawa
April 1987,
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K Kumagai, and
E Tashiro, and
N Tashiro, and
K Moroe, and
T Hiroki, and
K Arakawa
May 1972,
European journal of pharmacology,
K Kumagai, and
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K Arakawa
November 1983,
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K Kumagai, and
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K Kumagai, and
E Tashiro, and
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K Moroe, and
T Hiroki, and
K Arakawa
June 1987,
Masui. The Japanese journal of anesthesiology,
K Kumagai, and
E Tashiro, and
N Tashiro, and
K Moroe, and
T Hiroki, and
K Arakawa
August 1974,
The Tohoku journal of experimental medicine,
K Kumagai, and
E Tashiro, and
N Tashiro, and
K Moroe, and
T Hiroki, and
K Arakawa
August 1974,
Japanese journal of pharmacology,
K Kumagai, and
E Tashiro, and
N Tashiro, and
K Moroe, and
T Hiroki, and
K Arakawa
October 1973,
Japanese circulation journal,
K Kumagai, and
E Tashiro, and
N Tashiro, and
K Moroe, and
T Hiroki, and
K Arakawa
December 1987,
Masui. The Japanese journal of anesthesiology,
K Kumagai, and
E Tashiro, and
N Tashiro, and
K Moroe, and
T Hiroki, and
K Arakawa
October 1974,
Acta physiologica Scandinavica,
