-transparent.png){kind=logo}
A method is described for the synthesis, purification and radiolabelling of [123I/131I]2-[5-(4-iodophenyl)-pentyl]oxirane-2-carboxylic acid ethyl ester. For the synthesis of this new agent, 5-phenylpentyl bromide (1), synthesized by reacting 5-phenyl-1-pentanol with sodium bromide under acidic conditions, was converted to diethyl 5-phenylpentylmalonate (2), which, on alkaline hydrolysis, yielded ethyl 5-phenylpentylmalonate (3). Ethyl 7-phenyl-2-methyleneheptanoate (4), prepared from the monoester (3), was oxidized with m-chloroperbenzoic acid to yield ethyl 2-(5-phenylpentyl)oxirane-2-carboxylate 5. The method of radiolabelling, based on the thallation of compound (5) and the subsequent treatment with radioiodide, resulted in a regioselective radioiodination with a 54% radiochemical yield.
H G Abbas, and
M Younas, and
L E Feinendegen
August 1985,
Biochemical pharmacology,
H G Abbas, and
M Younas, and
L E Feinendegen
January 1964,
Bulletin of the Calcutta School of Tropical Medicine,
H G Abbas, and
M Younas, and
L E Feinendegen
March 2011,
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,
H G Abbas, and
M Younas, and
L E Feinendegen
November 1997,
Journal of medicinal chemistry,
H G Abbas, and
M Younas, and
L E Feinendegen
February 1984,
Biochemical pharmacology,
H G Abbas, and
M Younas, and
L E Feinendegen
February 1984,
Biochemical pharmacology,
H G Abbas, and
M Younas, and
L E Feinendegen
September 1997,
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
H G Abbas, and
M Younas, and
L E Feinendegen
April 2001,
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry,
H G Abbas, and
M Younas, and
L E Feinendegen
November 1984,
Biochemical pharmacology,
H G Abbas, and
M Younas, and
L E Feinendegen
May 2005,
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
