Evidence that very small embryonic-like stem cells are mobilized into peripheral blood. 2008

Magda J Kucia, and Marcin Wysoczynski, and Wan Wu, and Ewa K Zuba-Surma, and Janina Ratajczak, and Mariusz Z Ratajczak
Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 South Floyd Street, Room 107, Louisville, Kentucky 40202, USA. mzrata01@louisville.edu

Recently, we identified in murine adult tissues, including bone marrow, a population of very small embryonic-like (VSEL) stem cells. Here, we provide further evidence that under steady-state conditions these cells circulate at very low levels in peripheral blood (PB) ( approximately 100-200 cells/ml) and could be additionally mobilized during pharmacological granulocyte-colony-stimulating factor-induced or stress-related mobilization, as demonstrated in a model of toxic liver or skeletal muscle damage induced by injection of carbon tetrachloride or cardiotoxin, respectively. The number of circulating VSEL stem cells under steady-state conditions in PB of 2-month-old animals was five times higher than that in 1-year-old mice. In conclusion, this study supports a hypothesis that VSEL stem cells are a mobile pool of primitive stem cells that could be released from the stem cell niches into PB. Further studies are needed, however, to see whether the level of these cells circulating in PB could become a prognostic indicator to assess the regenerative potential of an adult organism and/or clinical outcome from an injury. Disclosure of potential conflicts of interest is found at the end of this article.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008565 Membrane Proteins Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors. Cell Membrane Protein,Cell Membrane Proteins,Cell Surface Protein,Cell Surface Proteins,Integral Membrane Proteins,Membrane-Associated Protein,Surface Protein,Surface Proteins,Integral Membrane Protein,Membrane Protein,Membrane-Associated Proteins,Membrane Associated Protein,Membrane Associated Proteins,Membrane Protein, Cell,Membrane Protein, Integral,Membrane Proteins, Integral,Protein, Cell Membrane,Protein, Cell Surface,Protein, Integral Membrane,Protein, Membrane,Protein, Membrane-Associated,Protein, Surface,Proteins, Cell Membrane,Proteins, Cell Surface,Proteins, Integral Membrane,Proteins, Membrane,Proteins, Membrane-Associated,Proteins, Surface,Surface Protein, Cell
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D001854 Bone Marrow Cells Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells. Bone Marrow Cell,Cell, Bone Marrow,Cells, Bone Marrow,Marrow Cell, Bone,Marrow Cells, Bone
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000950 Antigens, Ly A group of lymphocyte surface antigens located on mouse LYMPHOCYTES. Specific Ly antigens are useful markers for distinguishing subpopulations of lymphocytes. Ly Antigens
D016179 Granulocyte Colony-Stimulating Factor A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. Colony-Stimulating Factor, Granulocyte,G-CSF,Myeloid Growth Factor,Colony Stimulating Factor, Granulocyte,Factor, Granulocyte Colony-Stimulating,Factor, Myeloid Growth,Granulocyte Colony Stimulating Factor,Growth Factor, Myeloid
D016256 Lewis X Antigen A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, Lewis X antigen is a stage-specific embryonic antigen. Antigens, CD15,CD15 Antigens,Le(X) Antigen,Leu-M1 Antigens,Lewis X Related Antigens,SSEA-1,SSEA-1 Determinant,Stage-Specific Embryonic Antigen-1,3 alpha-Fucosyl-N-Acetyl Lactosamine,CD15 Antigen,Galbeta(1-4)Fucalpha(1-3)GlcNAc,Hapten X,Lewis X Hapten,SSEA 1,3 alpha Fucosyl N Acetyl Lactosamine,Antigen, Lewis X,Embryonic Antigen-1, Stage-Specific,Leu M1 Antigens,SSEA 1 Determinant,Stage Specific Embryonic Antigen 1,X Antigen, Lewis,X Hapten, Lewis

Related Publications

Magda J Kucia, and Marcin Wysoczynski, and Wan Wu, and Ewa K Zuba-Surma, and Janina Ratajczak, and Mariusz Z Ratajczak
April 2009, Stroke,
Magda J Kucia, and Marcin Wysoczynski, and Wan Wu, and Ewa K Zuba-Surma, and Janina Ratajczak, and Mariusz Z Ratajczak
March 2012, Stem cell reviews and reports,
Magda J Kucia, and Marcin Wysoczynski, and Wan Wu, and Ewa K Zuba-Surma, and Janina Ratajczak, and Mariusz Z Ratajczak
September 2012, Inflammatory bowel diseases,
Magda J Kucia, and Marcin Wysoczynski, and Wan Wu, and Ewa K Zuba-Surma, and Janina Ratajczak, and Mariusz Z Ratajczak
August 2017, Stem cell reviews and reports,
Magda J Kucia, and Marcin Wysoczynski, and Wan Wu, and Ewa K Zuba-Surma, and Janina Ratajczak, and Mariusz Z Ratajczak
January 2012, Methods in molecular biology (Clifton, N.J.),
Magda J Kucia, and Marcin Wysoczynski, and Wan Wu, and Ewa K Zuba-Surma, and Janina Ratajczak, and Mariusz Z Ratajczak
November 2013, Stem cells and development,
Magda J Kucia, and Marcin Wysoczynski, and Wan Wu, and Ewa K Zuba-Surma, and Janina Ratajczak, and Mariusz Z Ratajczak
May 2008, Journal of molecular and cellular cardiology,
Magda J Kucia, and Marcin Wysoczynski, and Wan Wu, and Ewa K Zuba-Surma, and Janina Ratajczak, and Mariusz Z Ratajczak
October 2006, Stem cells (Dayton, Ohio),
Magda J Kucia, and Marcin Wysoczynski, and Wan Wu, and Ewa K Zuba-Surma, and Janina Ratajczak, and Mariusz Z Ratajczak
January 2019, Circulation research,
Magda J Kucia, and Marcin Wysoczynski, and Wan Wu, and Ewa K Zuba-Surma, and Janina Ratajczak, and Mariusz Z Ratajczak
January 2016, Stem cells international,
Copied contents to your clipboard!