-transparent.png){kind=logo}
The serological responses of conventionally reared sheep were compared after vaccination with inactivated parainfluenza 3 (PI3) virus incorporated in three different adjuvants. Inactivated PI3 virus with the double-stranded RNA, BRL 5907 in an oil emulsion was shown to stimulate higher serum antibody titres over the first 5 weeks after vaccination than virus with and without BCG emulsified in oil. The ability of this vaccine to protect specific pathogen-free lambs against challenge with PI3 virus was examined in a second experiment. In this experiment the vaccine stimulated virus neutralizing and haemagglutination inhibiting antibodies in the serum. After intranasal and intratracheal inoculation with PI3 virus at challenge, vaccinated lambs showed no clinical illness and virus isolation was confined, except in one lamb, to the first two days. In contrast, unvaccinated lambs developed respiratory disease and virus was isolated daily for 7 days after challenge.
P W Wells, and
J M Sharp, and
C Burrells, and
B Rushton, and
W D Smith
July 1982,
The Journal of antimicrobial chemotherapy,
P W Wells, and
J M Sharp, and
C Burrells, and
B Rushton, and
W D Smith
May 1980,
Journal of the Reticuloendothelial Society,
P W Wells, and
J M Sharp, and
C Burrells, and
B Rushton, and
W D Smith
November 1974,
Research in veterinary science,
P W Wells, and
J M Sharp, and
C Burrells, and
B Rushton, and
W D Smith
October 1980,
Journal of the Reticuloendothelial Society,
P W Wells, and
J M Sharp, and
C Burrells, and
B Rushton, and
W D Smith
February 1976,
British journal of cancer,
P W Wells, and
J M Sharp, and
C Burrells, and
B Rushton, and
W D Smith
February 1976,
British journal of cancer,
P W Wells, and
J M Sharp, and
C Burrells, and
B Rushton, and
W D Smith
February 1967,
The American review of respiratory disease,
P W Wells, and
J M Sharp, and
C Burrells, and
B Rushton, and
W D Smith
September 1975,
Research in veterinary science,
P W Wells, and
J M Sharp, and
C Burrells, and
B Rushton, and
W D Smith
January 1982,
Acta veterinaria Academiae Scientiarum Hungaricae,
P W Wells, and
J M Sharp, and
C Burrells, and
B Rushton, and
W D Smith
June 2021,
Scientific reports,
