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The mammalian NAD+ dependent deacetylase, SIRT1, was shown to be a key protein in regulating glucose homeostasis, and was implicated in the response to calorie restriction. We show here that levels of SIRT1 increased in response to nutrient deprivation in cultured cells, and in multiple tissues of mice after fasting. The increase in SIRT1 levels was due to stabilization of SIRT1 protein, and not an increase in SIRT1 mRNA. In addition, p53 negatively regulated SIRT1 levels under normal growth conditions and is also required for the elevation of SIRT1 under limited nutrient conditions. These results have important implications on the relationship between sirtuins, nutrient availability and aging.
Yariv Kanfi, and
Victoria Peshti, and
Yosi M Gozlan, and
Moran Rathaus, and
Reuven Gil, and
Haim Y Cohen
October 2013,
Molecular and cellular biology,
Yariv Kanfi, and
Victoria Peshti, and
Yosi M Gozlan, and
Moran Rathaus, and
Reuven Gil, and
Haim Y Cohen
October 2008,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
Yariv Kanfi, and
Victoria Peshti, and
Yosi M Gozlan, and
Moran Rathaus, and
Reuven Gil, and
Haim Y Cohen
December 2004,
Science (New York, N.Y.),
Yariv Kanfi, and
Victoria Peshti, and
Yosi M Gozlan, and
Moran Rathaus, and
Reuven Gil, and
Haim Y Cohen
April 2007,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
Yariv Kanfi, and
Victoria Peshti, and
Yosi M Gozlan, and
Moran Rathaus, and
Reuven Gil, and
Haim Y Cohen
January 2018,
Molecular & cellular oncology,
Yariv Kanfi, and
Victoria Peshti, and
Yosi M Gozlan, and
Moran Rathaus, and
Reuven Gil, and
Haim Y Cohen
April 2014,
Biochimica et biophysica acta,
Yariv Kanfi, and
Victoria Peshti, and
Yosi M Gozlan, and
Moran Rathaus, and
Reuven Gil, and
Haim Y Cohen
June 2011,
International journal of medical microbiology : IJMM,
Yariv Kanfi, and
Victoria Peshti, and
Yosi M Gozlan, and
Moran Rathaus, and
Reuven Gil, and
Haim Y Cohen
March 2006,
Cell cycle (Georgetown, Tex.),
Yariv Kanfi, and
Victoria Peshti, and
Yosi M Gozlan, and
Moran Rathaus, and
Reuven Gil, and
Haim Y Cohen
June 2011,
The Journal of biological chemistry,
Yariv Kanfi, and
Victoria Peshti, and
Yosi M Gozlan, and
Moran Rathaus, and
Reuven Gil, and
Haim Y Cohen
May 2020,
Biochimica et biophysica acta. Molecular basis of disease,
