Amyloidosis results from the deposition of amyloid proteins in organ and tissues. It can be localized or systemic. Amyloidosis may be classified as either primary or secondary. Primary is idiopathic, whereas the secondary form is associated with chronic inflammatory or infectious process. Amyloidosis is also related to myeloma multiplex (plasmacytoma) or located as tumor like deposits in isolated organ without systemic involvement. Localized amyloidosis in the head and neck is rare and can have various manifestations. A case of surgically treated localized amyloidosis of the pharynx is presented. The study is focused on case history, results of laryngeal, general and pathological examination of the patient. Current options on the structure of amyloid, making diagnosis, treatment and prognosis in patients with amyloidosis are presented.